Traumatic Acid Reduces Oxidative Stress and Enhances Collagen Biosynthesis in Cultured Human Skin Fibroblasts

DOI PDF Web Site Web Site Web Site 被引用文献1件
  • Agata Jabłońska‐Trypuć
    Faculty of Civil and Environmental Engineering, Division of Sanitary Biology and Biotechnology Bialystok University of Technology Wiejska Street 45E Białystok 15‐351 Poland
  • Walentyn Pankiewicz
    University of Medical Science in Białystok Krakowska Street 9 Białystok 15‐875 Poland
  • Romuald Czerpak
    University of Medical Science in Białystok Krakowska Street 9 Białystok 15‐875 Poland

この論文をさがす

説明

<jats:title>Abstract</jats:title><jats:p>Traumatic acid (TA) is a plant hormone (cytokinin) that in terms of chemical structure belongs to the group of fatty acids derivatives. It was isolated from <jats:italic>Phaseolus vulgaris</jats:italic>. TA activity and its influence on human cells and organism has not previously been the subject of research. The aim of this study was to examine the effects of TA on collagen content and basic oxidative stress parameters, such as antioxidative enzyme activity, reduced glutathione, thiol group content, and lipid peroxidation in physiological conditions. The results show a stimulatory effect of TA on tested parameters. TA caused a decrease in membrane phospholipid peroxidation and exhibited protective properties against ROS production. It also increases protein and collagen biosynthesis and its secretion into the culture medium. The present findings reveal that TA exhibits multiple and complex activity in fibroblast cells <jats:italic>in vitro</jats:italic>. TA, with its activity similar to unsaturated fatty acids, shows antioxidant and stimulatory effects on collagen biosynthesis. It is a potentially powerful agent with applications in the treatment of many skin diseases connected with oxidative stress and collagen biosynthesis disorders.</jats:p>

収録刊行物

  • Lipids

    Lipids 51 (9), 1021-1035, 2016-07-16

    Wiley

被引用文献 (1)*注記

もっと見る

問題の指摘

ページトップへ