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- Pasquale Picone
- Istituto di Biomedicina ed Immunologia Molecolare (IBIM) “Alberto Monroy,” CNR, via Ugo La Malfa 153, 90146 Palermo, Italy
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- Domenico Nuzzo
- Istituto di Biomedicina ed Immunologia Molecolare (IBIM) “Alberto Monroy,” CNR, via Ugo La Malfa 153, 90146 Palermo, Italy
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- Luca Caruana
- Istituto di Biomedicina ed Immunologia Molecolare (IBIM) “Alberto Monroy,” CNR, via Ugo La Malfa 153, 90146 Palermo, Italy
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- Valeria Scafidi
- Istituto di Biomedicina ed Immunologia Molecolare (IBIM) “Alberto Monroy,” CNR, via Ugo La Malfa 153, 90146 Palermo, Italy
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- Marta Di Carlo
- Istituto di Biomedicina ed Immunologia Molecolare (IBIM) “Alberto Monroy,” CNR, via Ugo La Malfa 153, 90146 Palermo, Italy
抄録
<jats:p>Mitochondria are dynamic ATP-generating organelle which contribute to many cellular functions including bioenergetics processes, intracellular calcium regulation, alteration of reduction-oxidation potential of cells, free radical scavenging, and activation of caspase mediated cell death. Mitochondrial functions can be negatively affected by amyloid<jats:italic>β</jats:italic>peptide (A<jats:italic>β</jats:italic>), an important component in Alzheimer’s disease (AD) pathogenesis, and A<jats:italic>β</jats:italic>can interact with mitochondria and cause mitochondrial dysfunction. One of the most accepted hypotheses for AD onset implicates that mitochondrial dysfunction and oxidative stress are one of the primary events in the insurgence of the pathology. Here, we examine structural and functional mitochondrial changes in presence of A<jats:italic>β</jats:italic>. In particular we review data concerning A<jats:italic>β</jats:italic>import into mitochondrion and its involvement in mitochondrial oxidative stress, bioenergetics, biogenesis, trafficking, mitochondrial permeability transition pore (mPTP) formation, and mitochondrial protein interaction. Moreover, the development of AD therapy targeting mitochondria is also discussed.</jats:p>
収録刊行物
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- Oxidative Medicine and Cellular Longevity
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Oxidative Medicine and Cellular Longevity 2014 1-11, 2014
Hindawi Limited