Outcomes of Critically Ill Patients With Hematologic Malignancies: Prospective Multicenter Data From France and Belgium—A Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique Study
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- Elie Azoulay
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Djamel Mokart
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Frédéric Pène
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Jérôme Lambert
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Achille Kouatchet
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Julien Mayaux
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- François Vincent
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Martine Nyunga
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Fabrice Bruneel
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Louise-Marie Laisne
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Antoine Rabbat
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Christine Lebert
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Pierre Perez
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Marine Chaize
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Anne Renault
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Anne-Pascale Meert
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Dominique Benoit
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Rebecca Hamidfar
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Mercé Jourdain
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Michael Darmon
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Benoit Schlemmer
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Sylvie Chevret
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
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- Virginie Lemiale
- Elie Azoulay, Jérôme Lambert, Louise-Marie Laisne, Marine Chaize, Benoit Schlemmer, Sylvie Chevret, and Virginie Lemiale, Saint-Louis Hospital; Frédéric Pène, Cochin Hospital; Julien Mayaux, Pitié-Salpétrière Hospital; Antoine Rabbat, Hôtel Dieu Hospital, Paris; Djamel Mokart, Institut Paoli Calmette, Marseille; Achille Kouatchet, Centre Hospitalier Universitaire Hospital, Angers; François Vincent, Avicenne Hospital, Bobigny; Martine Nyunga, Victor Provo Hospital, Roubaix; Fabrice Bruneel, Mignot...
説明
<jats:sec><jats:title>Purpose</jats:title><jats:p> Patients with hematologic malignancies are increasingly admitted to the intensive care unit (ICU) when life-threatening events occur. We sought to report outcomes and prognostic factors in these patients. </jats:p></jats:sec><jats:sec><jats:title>Patients and Methods</jats:title><jats:p> Ours was a prospective, multicenter cohort study of critically ill patients with hematologic malignancies. Health-related quality of life (HRQOL) and disease status were collected after 3 to 6 months. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Of the 1,011 patients, 38.2% had newly diagnosed malignancies, 23.1% were in remission, and 24.9% had received hematopoietic stem-cell transplantations (HSCT, including 145 allogeneic). ICU admission was mostly required for acute respiratory failure (62.5%) and/or shock (42.3%). On day1, 733 patients (72.5%) received life-supporting interventions. Hospital, day-90, and 1-year survival rates were 60.7%, 52.5%, and 43.3%, respectively. By multivariate analysis, cancer remission and time to ICU admission less than 24 hours were associated with better hospital survival. Poor performance status, Charlson comorbidity index, allogeneic HSCT, organ dysfunction score, cardiac arrest, acute respiratory failure, malignant organ infiltration, and invasive aspergillosis were associated with higher hospital mortality. Mechanical ventilation (47.9% of patients), vasoactive drugs (51.2%), and dialysis (25.9%) were associated with mortality rates of 60.5%, 57.5%, and 59.2%, respectively. On day 90, 80% of survivors had no HRQOL alterations (physical and mental health similar to that of the overall cancer population). After 6 months, 80% of survivors had no change in treatment intensity compared with similar patients not admitted to the ICU, and 80% were in remission. </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> Critically ill patients with hematologic malignancies have good survival, disease control, and post-ICU HRQOL. Earlier ICU admission is associated with better survival. </jats:p></jats:sec>
収録刊行物
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- Journal of Clinical Oncology
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Journal of Clinical Oncology 31 (22), 2810-2818, 2013-08-01
American Society of Clinical Oncology (ASCO)