Blunted neural response to rewards prospectively predicts depression in adolescent girls
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- Jennifer N. Bress
- Department of Psychology Stony Brook University, Stony Brook New York USA
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- Dan Foti
- Department of Psychology Stony Brook University, Stony Brook New York USA
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- Roman Kotov
- Department of Psychiatry and Behavioral Sciences Stony Brook University, Stony Brook New York USA
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- Daniel N. Klein
- Department of Psychology Stony Brook University, Stony Brook New York USA
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- Greg Hajcak
- Department of Psychology Stony Brook University, Stony Brook New York USA
説明
<jats:title>Abstract</jats:title><jats:p>The prevalence of depression increases substantially during adolescence. Several predictors of major depressive disorder have been established, but their predictive power is limited. In the current study, the feedback negativity (<jats:styled-content style="fixed-case">FN</jats:styled-content>), an event‐related potential component elicited by feedback indicating monetary gain versus loss, was recorded in 68 never‐depressed adolescent girls. Over the following 2 years, 24% of participants developed a major depressive episode (<jats:styled-content style="fixed-case">MDE</jats:styled-content>); illness onset was predicted by blunted <jats:styled-content style="fixed-case">FN</jats:styled-content> at initial evaluation. Lower <jats:styled-content style="fixed-case">FN</jats:styled-content> amplitude predicted more depressive symptoms during the follow‐up period, even after controlling for neuroticism and depressive symptoms at baseline. This is the first prospective study to demonstrate a link between a neural measure of reward sensitivity and the first onset of an <jats:styled-content style="fixed-case">MDE</jats:styled-content>. The current results suggest that low reward sensitivity may be an important factor in the development of depression.</jats:p>
収録刊行物
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- Psychophysiology
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Psychophysiology 50 (1), 74-81, 2012-12-18
Wiley