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Chromatin accessibility dynamics in a model of human forebrain development
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- Alexandro E. Trevino
- Department of Bioengineering, Stanford University, Stanford, CA, USA.
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- Nasa Sinnott-Armstrong
- Department of Genetics, Stanford University, Stanford, CA, USA.
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- Jimena Andersen
- Stanford Human Brain Organogenesis Program, Stanford, CA, USA.
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- Se-Jin Yoon
- Department of Genetics, Stanford University, Stanford, CA, USA.
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- Nina Huber
- Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
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- Jonathan K. Pritchard
- Department of Genetics, Stanford University, Stanford, CA, USA.
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- Howard Y. Chang
- Department of Genetics, Stanford University, Stanford, CA, USA.
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- William J. Greenleaf
- Department of Genetics, Stanford University, Stanford, CA, USA.
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- Sergiu P. Pașca
- Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
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Description
<jats:title>Organoids recapitulate brain development</jats:title> <jats:p> Gene expression changes and their control by accessible chromatin in the human brain during development is of great interest but limited accessibility. Trevino <jats:italic>et al.</jats:italic> avoided this problem by developing three-dimensional organoid models of human forebrain development and examining chromatin accessibility and gene expression at the single-cell level. From this analysis, they matched developmental profiles between the organoid and fetal samples, identified transcription factor binding profiles, and predicted how transcription factors are linked to cortical development. The researchers were able to correlate the expression of neurodevelopmental disease risk loci and genes with specific cell types during development. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aay1645">eaay1645</jats:related-article> </jats:p>
Journal
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- Science
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Science 367 (6476), 0-, 2020-01-24
American Association for the Advancement of Science (AAAS)
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Details 詳細情報について
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- CRID
- 1360574096016335744
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- ISSN
- 10959203
- 00368075
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- Data Source
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- Crossref