Lifestyle and Horizontal Gene Transfer-Mediated Evolution of Mucispirillum schaedleri, a Core Member of the Murine Gut Microbiota
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- Alexander Loy
- Division of Microbial Ecology, Department of Microbiology and Ecosystem Science, University of Vienna, Austria
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- Carina Pfann
- Division of Microbial Ecology, Department of Microbiology and Ecosystem Science, University of Vienna, Austria
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- Michaela Steinberger
- Division of Microbial Ecology, Department of Microbiology and Ecosystem Science, University of Vienna, Austria
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- Buck Hanson
- Division of Microbial Ecology, Department of Microbiology and Ecosystem Science, University of Vienna, Austria
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- Simone Herp
- Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Ludwig Maximilians University of Munich, and German Center for Infection Research (DZIF), Partner Site LMU Munich, Munich, Germany
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- Sandrine Brugiroux
- Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Ludwig Maximilians University of Munich, and German Center for Infection Research (DZIF), Partner Site LMU Munich, Munich, Germany
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- João Carlos Gomes Neto
- Food Science and Technology Department, University of Nebraska—Lincoln, Lincoln, Nebraska, USA
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- Mark V. Boekschoten
- Nutrition, Metabolism, and Genomics Group, Wageningen University, Wageningen, the Netherlands
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- Clarissa Schwab
- Archaea Biology and Ecogenomics Division, Department of Ecogenomics and Systems Biology, University of Vienna, Vienna, Austria
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- Tim Urich
- Archaea Biology and Ecogenomics Division, Department of Ecogenomics and Systems Biology, University of Vienna, Vienna, Austria
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- Amanda E. Ramer-Tait
- Food Science and Technology Department, University of Nebraska—Lincoln, Lincoln, Nebraska, USA
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- Thomas Rattei
- Division of Computational Systems Biology, Department of Microbiology and Ecosystem Science, University of Vienna, Vienna, Austria
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- Bärbel Stecher
- Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Ludwig Maximilians University of Munich, and German Center for Infection Research (DZIF), Partner Site LMU Munich, Munich, Germany
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- David Berry
- Division of Microbial Ecology, Department of Microbiology and Ecosystem Science, University of Vienna, Austria
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- Catherine Lozupone
- editor
書誌事項
- 公開日
- 2017-02-28
- 権利情報
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- http://creativecommons.org/licenses/by/4.0/
- https://journals.asm.org/non-commercial-tdm-license
- DOI
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- 10.1128/msystems.00171-16
- 公開者
- American Society for Microbiology
説明
<jats:p> Shifts in gut microbiota composition have been associated with intestinal inflammation, but it remains unclear whether inflammation-associated bacteria are commensal or detrimental to their host. Here, we studied the lifestyle of the gut bacterium <jats:named-content content-type="genus-species">Mucispirillum schaedleri</jats:named-content> , which is associated with inflammation in widely used mouse models. We found that <jats:italic>M. schaedleri</jats:italic> has specialized systems to handle oxidative stress during inflammation. Additionally, it expresses secretion systems and effector proteins and can modify the mucosal gene expression of its host. This suggests that <jats:italic>M. schaedleri</jats:italic> undergoes intimate interactions with its host and may play a role in inflammation. The insights presented here aid our understanding of how commensal gut bacteria may be involved in altering susceptibility to disease. </jats:p>
収録刊行物
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- mSystems
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mSystems 2 (1), 2017-02-28
American Society for Microbiology