Optimized Synthesis and Enhanced Efficacy of Novel Triplex-Forming Camptothecin Derivatives Based on Gimatecan

  • Pierre Vekhoff
    CNRS UMR5153, Muséum National d’Histoire Naturelle USM0503, and INSERM U565, 43 rue Cuvier, 75231 Paris cedex 05, France, UPMC, Paris 75005, France, DISMA, Università di Milano, via Celoria 2, 20133 Milano, Italy, INSERM U-837, COL, IRCL, Place Verdun, 59045 Lille, France, and Sigma-tau Industrie Farmaceutiche Riunite SpA, Pomezia, Italy
  • Ludovic Halby
    CNRS UMR5153, Muséum National d’Histoire Naturelle USM0503, and INSERM U565, 43 rue Cuvier, 75231 Paris cedex 05, France, UPMC, Paris 75005, France, DISMA, Università di Milano, via Celoria 2, 20133 Milano, Italy, INSERM U-837, COL, IRCL, Place Verdun, 59045 Lille, France, and Sigma-tau Industrie Farmaceutiche Riunite SpA, Pomezia, Italy
  • Kahina Oussedik
    CNRS UMR5153, Muséum National d’Histoire Naturelle USM0503, and INSERM U565, 43 rue Cuvier, 75231 Paris cedex 05, France, UPMC, Paris 75005, France, DISMA, Università di Milano, via Celoria 2, 20133 Milano, Italy, INSERM U-837, COL, IRCL, Place Verdun, 59045 Lille, France, and Sigma-tau Industrie Farmaceutiche Riunite SpA, Pomezia, Italy
  • Sabrina Dallavalle
    CNRS UMR5153, Muséum National d’Histoire Naturelle USM0503, and INSERM U565, 43 rue Cuvier, 75231 Paris cedex 05, France, UPMC, Paris 75005, France, DISMA, Università di Milano, via Celoria 2, 20133 Milano, Italy, INSERM U-837, COL, IRCL, Place Verdun, 59045 Lille, France, and Sigma-tau Industrie Farmaceutiche Riunite SpA, Pomezia, Italy
  • Lucio Merlini
    CNRS UMR5153, Muséum National d’Histoire Naturelle USM0503, and INSERM U565, 43 rue Cuvier, 75231 Paris cedex 05, France, UPMC, Paris 75005, France, DISMA, Università di Milano, via Celoria 2, 20133 Milano, Italy, INSERM U-837, COL, IRCL, Place Verdun, 59045 Lille, France, and Sigma-tau Industrie Farmaceutiche Riunite SpA, Pomezia, Italy
  • Christine Mahieu
    CNRS UMR5153, Muséum National d’Histoire Naturelle USM0503, and INSERM U565, 43 rue Cuvier, 75231 Paris cedex 05, France, UPMC, Paris 75005, France, DISMA, Università di Milano, via Celoria 2, 20133 Milano, Italy, INSERM U-837, COL, IRCL, Place Verdun, 59045 Lille, France, and Sigma-tau Industrie Farmaceutiche Riunite SpA, Pomezia, Italy
  • Amélie Lansiaux
    CNRS UMR5153, Muséum National d’Histoire Naturelle USM0503, and INSERM U565, 43 rue Cuvier, 75231 Paris cedex 05, France, UPMC, Paris 75005, France, DISMA, Università di Milano, via Celoria 2, 20133 Milano, Italy, INSERM U-837, COL, IRCL, Place Verdun, 59045 Lille, France, and Sigma-tau Industrie Farmaceutiche Riunite SpA, Pomezia, Italy
  • Christian Bailly
    CNRS UMR5153, Muséum National d’Histoire Naturelle USM0503, and INSERM U565, 43 rue Cuvier, 75231 Paris cedex 05, France, UPMC, Paris 75005, France, DISMA, Università di Milano, via Celoria 2, 20133 Milano, Italy, INSERM U-837, COL, IRCL, Place Verdun, 59045 Lille, France, and Sigma-tau Industrie Farmaceutiche Riunite SpA, Pomezia, Italy
  • Alexandre Boutorine
    CNRS UMR5153, Muséum National d’Histoire Naturelle USM0503, and INSERM U565, 43 rue Cuvier, 75231 Paris cedex 05, France, UPMC, Paris 75005, France, DISMA, Università di Milano, via Celoria 2, 20133 Milano, Italy, INSERM U-837, COL, IRCL, Place Verdun, 59045 Lille, France, and Sigma-tau Industrie Farmaceutiche Riunite SpA, Pomezia, Italy
  • Claudio Pisano
    CNRS UMR5153, Muséum National d’Histoire Naturelle USM0503, and INSERM U565, 43 rue Cuvier, 75231 Paris cedex 05, France, UPMC, Paris 75005, France, DISMA, Università di Milano, via Celoria 2, 20133 Milano, Italy, INSERM U-837, COL, IRCL, Place Verdun, 59045 Lille, France, and Sigma-tau Industrie Farmaceutiche Riunite SpA, Pomezia, Italy
  • Giuseppe Giannini
    CNRS UMR5153, Muséum National d’Histoire Naturelle USM0503, and INSERM U565, 43 rue Cuvier, 75231 Paris cedex 05, France, UPMC, Paris 75005, France, DISMA, Università di Milano, via Celoria 2, 20133 Milano, Italy, INSERM U-837, COL, IRCL, Place Verdun, 59045 Lille, France, and Sigma-tau Industrie Farmaceutiche Riunite SpA, Pomezia, Italy
  • Domenico Alloatti
    CNRS UMR5153, Muséum National d’Histoire Naturelle USM0503, and INSERM U565, 43 rue Cuvier, 75231 Paris cedex 05, France, UPMC, Paris 75005, France, DISMA, Università di Milano, via Celoria 2, 20133 Milano, Italy, INSERM U-837, COL, IRCL, Place Verdun, 59045 Lille, France, and Sigma-tau Industrie Farmaceutiche Riunite SpA, Pomezia, Italy
  • Paola B. Arimondo
    CNRS UMR5153, Muséum National d’Histoire Naturelle USM0503, and INSERM U565, 43 rue Cuvier, 75231 Paris cedex 05, France, UPMC, Paris 75005, France, DISMA, Università di Milano, via Celoria 2, 20133 Milano, Italy, INSERM U-837, COL, IRCL, Place Verdun, 59045 Lille, France, and Sigma-tau Industrie Farmaceutiche Riunite SpA, Pomezia, Italy

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