Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
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- Michael J. Gandal
- Program in Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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- Jillian R. Haney
- Program in Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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- Neelroop N. Parikshak
- Program in Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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- Virpi Leppa
- Program in Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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- Gokul Ramaswami
- Program in Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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- Chris Hartl
- Program in Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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- Andrew J. Schork
- Institute of Biological Psychiatry, Mental Health Services Copenhagen, Copenhagen, Denmark.
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- Vivek Appadurai
- Institute of Biological Psychiatry, Mental Health Services Copenhagen, Copenhagen, Denmark.
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- Alfonso Buil
- Institute of Biological Psychiatry, Mental Health Services Copenhagen, Copenhagen, Denmark.
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- Thomas M. Werge
- Institute of Biological Psychiatry, Mental Health Services Copenhagen, Copenhagen, Denmark.
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- Chunyu Liu
- Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60607, USA.
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- Kevin P. White
- Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
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- Steve Horvath
- Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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- Daniel H. Geschwind
- Program in Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
説明
<jats:title>Genes overlap across psychiatric disease</jats:title> <jats:p> Many genome-wide studies have examined genes associated with a range of neuropsychiatric disorders. However, the degree to which the genetic underpinnings of these diseases differ or overlap is unknown. Gandal <jats:italic>et al.</jats:italic> performed meta-analyses of transcriptomic studies covering five major psychiatric disorders and compared cases and controls to identify coexpressed gene modules. From this, they found that some psychiatric disorders share global gene expression patterns. This overlap in polygenic traits in neuropsychiatric disorders may allow for better diagnosis and treatment. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6376" page="693" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aad6469">693</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 359 (6376), 693-697, 2018-02-09
American Association for the Advancement of Science (AAAS)
