Tandem <i>Z</i>‐Selective Cross‐Metathesis/Dihydroxylation: Synthesis of <i>anti</i>‐1,2‐Diols

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<jats:title>Abstract</jats:title><jats:p>A stereoselective synthesis of <jats:italic>anti</jats:italic>‐1,2‐diols has been developed using a multitasking Ru catalyst in an assisted tandem catalysis protocol. A cyclometalated Ru complex catalyzes first a <jats:italic>Z</jats:italic>‐selective cross‐metathesis of two terminal olefins, followed by a stereospecific dihydroxylation. Both steps are catalyzed by Ru, as the Ru complex is converted to a dihydroxylation catalyst upon addition of NaIO<jats:sub>4</jats:sub>. A variety of olefins were transformed into valuable, highly functionalized, and stereodefined molecules. Mechanistic experiments were performed to probe the nature of the oxidation step and catalyst inhibition pathways. These experiments point the way to more broadly applicable tandem catalytic transformations.</jats:p>

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