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- Marina M. Bellet
- Center for Epigenetics and Metabolism, Department of Biological Chemistry, and
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- Elisa Deriu
- Department of Microbiology and Molecular Genetics, Institute for Immunology, School of Medicine,
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- Janet Z. Liu
- Department of Microbiology and Molecular Genetics, Institute for Immunology, School of Medicine,
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- Benedetto Grimaldi
- Center for Epigenetics and Metabolism, Department of Biological Chemistry, and
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- Christoph Blaschitz
- Department of Microbiology and Molecular Genetics, Institute for Immunology, School of Medicine,
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- Michael Zeller
- Department of Computer Science, Institute for Genomics and Bioinformatics, and
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- Robert A. Edwards
- Department of Pathology, University of California, Irvine, CA 92697; and
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- Saurabh Sahar
- Center for Epigenetics and Metabolism, Department of Biological Chemistry, and
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- Satya Dandekar
- Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616
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- Pierre Baldi
- Department of Computer Science, Institute for Genomics and Bioinformatics, and
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- Michael D. George
- Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616
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- Manuela Raffatellu
- Department of Microbiology and Molecular Genetics, Institute for Immunology, School of Medicine,
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- Paolo Sassone-Corsi
- Center for Epigenetics and Metabolism, Department of Biological Chemistry, and
説明
<jats:p> Organisms adapt to day–night cycles through highly specialized circadian machinery, whose molecular components anticipate and drive changes in organism behavior and metabolism. Although many effectors of the immune system are known to follow daily oscillations, the role of the circadian clock in the immune response to acute infections is not understood. Here we show that the circadian clock modulates the inflammatory response during acute infection with the pathogen <jats:italic>Salmonella enterica</jats:italic> serovar Typhimurium ( <jats:italic>S.</jats:italic> Typhimurium). Mice infected with <jats:italic>S.</jats:italic> Typhimurium were colonized to higher levels and developed a higher proinflammatory response during the early rest period for mice, compared with other times of the day. We also demonstrate that a functional clock is required for optimal <jats:italic>S.</jats:italic> Typhimurium colonization and maximal induction of several proinflammatory genes. These findings point to a clock-regulated mechanism of activation of the immune response against an enteric pathogen and may suggest potential therapeutic strategies for chronopharmacologic interventions. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 110 (24), 9897-9902, 2013-05-28
Proceedings of the National Academy of Sciences
