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The genetics of Kawasaki disease
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- Yoshihiro Onouchi
- Department of Public Health Chiba University Graduate School of Medicine Chiba Japan
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Description
<jats:title>Abstract</jats:title><jats:p>Kawasaki disease (<jats:styled-content style="fixed-case">KD</jats:styled-content>) is a complex disorder which affects genetically susceptible infants and children. Several susceptibility genes (e.g., <jats:italic><jats:styled-content style="fixed-case">ITPKC</jats:styled-content></jats:italic>,<jats:italic> <jats:styled-content style="fixed-case">CASP</jats:styled-content>3</jats:italic>,<jats:italic> <jats:styled-content style="fixed-case">CD</jats:styled-content>40</jats:italic> and <jats:italic><jats:styled-content style="fixed-case">ORAI</jats:styled-content></jats:italic>) and chromosomal regions have been identified through genome‐wide association and genome‐wide linkage studies to have association with <jats:styled-content style="fixed-case">KD</jats:styled-content>. Knowledge of susceptibility genes involved in the pathogenesis of <jats:styled-content style="fixed-case">KD</jats:styled-content> may provide new insights into diagnosis and treatment of this condition. However, there is much that we still do not know about the genetic basis of <jats:styled-content style="fixed-case">KD</jats:styled-content>.</jats:p>
Journal
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- International Journal of Rheumatic Diseases
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International Journal of Rheumatic Diseases 21 (1), 26-30, 2017-11-19
Wiley