Distinct phosphorylation sites in a prototypical GPCR differently orchestrate β-arrestin interaction, trafficking, and signaling
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- Hemlata Dwivedi-Agnihotri
- Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
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- Madhu Chaturvedi
- Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
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- Mithu Baidya
- Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
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- Tomasz Maciej Stepniewski
- Research Programme on Biomedical Informatics (GRIB), Department of Experimental and Health Sciences of Pompeu Fabra University (UPF)-Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain.
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- Shubhi Pandey
- Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
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- Jagannath Maharana
- Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
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- Ashish Srivastava
- Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
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- Natarin Caengprasath
- Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Hammersmith Campus, Imperial College London, Du Cane Road, London, W12 0NN, UK.
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- Aylin C. Hanyaloglu
- Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Hammersmith Campus, Imperial College London, Du Cane Road, London, W12 0NN, UK.
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- Jana Selent
- Research Programme on Biomedical Informatics (GRIB), Department of Experimental and Health Sciences of Pompeu Fabra University (UPF)-Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain.
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- Arun K. Shukla
- Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
抄録
<jats:p>GPCR–β-arrestin interaction and signaling are differentially regulated by distinct phosphorylation sites on the receptor.</jats:p>
収録刊行物
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- Science Advances
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Science Advances 6 (37), eabb8368-, 2020-09-11
American Association for the Advancement of Science (AAAS)