An Acellular Biologic Scaffold Promotes Skeletal Muscle Formation in Mice and Humans with Volumetric Muscle Loss

DOI Web Site 7 Citations
  • Brian M. Sicari
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
  • J. Peter Rubin
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
  • Christopher L. Dearth
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
  • Matthew T. Wolf
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
  • Fabrisia Ambrosio
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
  • Michael Boninger
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
  • Neill J. Turner
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
  • Douglas J. Weber
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA.
  • Tyler W. Simpson
    Department of Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15219, USA.
  • Aaron Wyse
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15219, USA.
  • Elke H. P. Brown
    Department of Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15219, USA.
  • Jenna L. Dziki
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
  • Lee E. Fisher
    Department of Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15219, USA.
  • Spencer Brown
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
  • Stephen F. Badylak
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.

Description

<jats:p>Scaffolds composed of cell-free extracellular matrix promote de novo formation of functional skeletal muscle tissue in sites of volumetric muscle loss.</jats:p>

Journal

  • Science Translational Medicine

    Science Translational Medicine 6 (234), 234ra58-, 2014-04-30

    American Association for the Advancement of Science (AAAS)

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