Severe Thrombotic Microangiopathy Associated with Brucellosis: Successful Treatment with Plasmapheresis

DOI Web Site 1 Citations
  • Fevzi Altuntas
    Department of Hematology-Oncology, Erciyes University, Faculty of Medicine, Dedeman Hematology-Oncology Hospital, Kayseri, Turkey
  • Bülent Eser
    Department of Hematology-Oncology, Erciyes University, Faculty of Medicine, Dedeman Hematology-Oncology Hospital, Kayseri, Turkey
  • İsmail Sarı
    Department of Hematology-Oncology, Erciyes University, Faculty of Medicine, Dedeman Hematology-Oncology Hospital, Kayseri, Turkey
  • Orhan Yildiz
    Department of Clinical Microbiology and Infectious Diseases, Erciyes University, Faculty of Medicine, Dedeman Hematology-Oncology Hospital, Kayseri, Turkey
  • Mustafa Çetin
    Department of Hematology-Oncology, Erciyes University, Faculty of Medicine, Dedeman Hematology-Oncology Hospital, Kayseri, Turkey
  • Ali Ünal
    Department of Hematology-Oncology, Erciyes University, Faculty of Medicine, Dedeman Hematology-Oncology Hospital, Kayseri, Turkey

Description

<jats:p> Brucellosis is a disease that may lead to changes in hematologic parameters such as anemia, neutropenia, and thrombocytopenia; however, thrombotic microangiopathy (TMA) is a rare finding. Severe TMA may be associated with life-threatening hematologic, renal, and neurologic disorders. To prevent this mortality caused by brucellosis, prompt recognition of this complication and prompt therapy are essential. A patient with TMA associated with Brucella melitensis is presented who initially presented with fever, skin purpura, epistaxis, confusion, microangiopathic hemolytic anemia, and thrombocytopenia. TMA was treated with plasmapheresis with cryosupernatant plasma replacement, energetically. A rapid improvement in platelet count, lactate dehydrogenase level, hemolytic anemia, and neurologic symptoms was observed with this treatment. For cases with infection-induced thrombotic microangiopathy, short-term plasmapheresis may be applied as an urgent therapy in addition to antimicrobial therapy. </jats:p>

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