Mammalian in vitro gametogenesis

DOI Web Site 8 Citations 133 References Open Access
  • Mitinori Saitou
    Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
  • Katsuhiko Hayashi
    Department of Developmental Stem Cell Biology, Faculty of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.

Description

<jats:title>Reconstituting reproduction in culture</jats:title> <jats:p>Research on in vitro gametogenesis (IVG) aims to reconstitute germ cell development, oogenesis and spermatogenesis, in culture. Saitou and Hayashi review some of the recent developments in mammalian IVG. Advances in methods and culture conditions in mice to generate mature oocytes and spermatocytes from pluripotent stem cells have informed similar studies with nonhuman primate and human cells, but differences among species are clear. IVG has great potential for reproductive medicine, including novel diagnosis and modeling of infertility. The realization of human IVG requires further intensive efforts, but as technical hurtles are overcome, careful consideration must be given to the potential application of methods for reproductive purposes. —BAP</jats:p>

Journal

  • Science

    Science 374 (6563), eaaz6830-, 2021-10

    American Association for the Advancement of Science (AAAS)

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