Associations of Systolic Blood Pressure and Diastolic Blood Pressure With the Incidence of Coronary Artery Disease or Cerebrovascular Disease According to Glucose Status

<jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>To determine associations of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with new-onset coronary artery disease (CAD) or cerebrovascular disease (CVD) according to glucose status.</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>Examined was a nationwide claims database from 2008 to 2016 on 593,196 individuals. A Cox proportional hazards model identified risks of CAD and CVD events among five levels of SBP and DBP.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>During the study period 2,240 CAD and 3,207 CVD events occurred. Compared with SBP ≤119 mmHg, which was the lowest quintile of SBP, hazard ratios (95% CI) for CAD/CVD in the 4 higher quintiles (120–129, 130–139, 140–149, ≥150 mmHg) gradually increased from 2.10 (1.73–2.56)/1.46 (1.27–1.68) in quintile 2 to 3.21 (2.37–4.34)/4.76 (3.94–5.75) in quintile 5 for normoglycemia, from 1.39 (1.14–1.69)/1.70 (1.44–2.01) in quintile 2 to 2.52 (1.95–3.26)/4.12 (3.38–5.02) in quintile 5 for borderline glycemia, and from 1.50 (1.19–1.90)/1.72 (1.31–2.26) in quintile 2 to 2.52 (1.95–3.26)/3.54 (2.66–4.70) in quintile 5 for diabetes. A similar trend was observed for DBP across 4 quintiles (75–79, 80–84, 85–89, and ≥90 mmHg) compared with ≥74 mmHg, which was the lowest quintile.</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>Results indicated that cardiovascular risks gradually increased with increases in SBP and DBP regardless of the presence of and degree of a glucose abnormality. Further interventional trials are required to apply findings from this cohort study to clinical practice.</jats:p> </jats:sec>