Favorable therapeutic efficacy of low‐density lipoprotein apheresis for nephrotic syndrome with impaired renal function

  • Eri Muso
    Department of Food and Nutrition, Faculty of Contemporary Home Economics Kyoto Kacho University Kyoto Japan
  • Soichi Sakai
    Siratori Clinic Tokyo Japan
  • Youske Ogura
    Zenjinkai Ueno Hospital Tokyo Japan
  • Susumu Yukawa
    Hakubunnkai Kodama Hospital Wakayama Japan
  • Yoshiki Nishizawa
    University Public Corporation Osaka Osaka Japan
  • Noriaki Yorioka
    Hiroshima Kidney Organization Hiroshima Japan
  • Takao Saito
    Sanko Clinic Fukuoka Japan
  • Masatoshi Mune
    Ryoshukai Fujii Hospital Kishiwada Japan
  • Satoshi Sugiyama
    Kanayama Clinic Nagoya Japan
  • Yasuhiko Iino
    Tokyo Medical School Tokyo Japan
  • Tsutomu Hirano
    Diabetes Center Ebina General Hospital Ebina Japan
  • Motoshi Hattori
    Department of Pediatric Nephrology Tokyo Women's Medical University Tokyo Japan
  • Tsuyoshi Watanabe
    Tokyo‐kita Medical Center Tokyo Japan
  • Hitoshi Yokoyama
    Department of Nephrology Kanazawa Medical University School of Medicine Uchinada Japan
  • Hiroshi Sato
    Sendai Hospital of East Japan Railway Company Sendai Japan
  • Shunya Uchida
    Department of Health Care Teikyo Heisei University Tokyo Japan
  • Takashi Wada
    Department of Nephrology and Laboratory Medicine Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University Kanazawa Japan
  • Tetsuo Shoji
    Department of Vascular Medicine Osaka City University Graduate School of Medicine Osaka Japan
  • Hiroaki Oda
    Oda Clinic Hiroshima Japan
  • Kiyoshi Mori
    School of Pharmaceutical Sciences, University of Shizuoka Shizuoka Japan
  • Hideki Kimura
    Department of Clinical Laboratory University of Fukui Hospital Fukui Japan
  • Osamu Ito
    Division of General Medicine and Rehabilitation Tohoku Medical and Pharmaceutical University Faculty of Medicine Sendai Japan
  • Akira Nishiyama
    Department of Pharmacology, Faculty of Medicine Kagawa University Kagawa Japan
  • Shoichi Maruyama
    Department of Nephrology Nagoya University Graduate School of Medicine Nagoya Japan
  • Reiko Inagi
    Division of CKD Pathophysiology The University of Tokyo Graduate School of Medicine Tokyo Japan
  • Shoichi Fujimoto
    Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine University of Miyazaki Miyazaki Japan
  • Tatsuo Tsukamoto
    Department of Nephrology and Dialysis Kitano Hospital, Tazuke Kofukai Medical Research Institute Osaka Japan
  • Yusuke Suzuki
    Department of Nephrology Juntendo University Faculty of Medicine Tokyo Japan
  • Hirokazu Honda
    Department of Medicine, Division of Nephrology Showa University School of Medicine Tokyo Japan
  • Tetsuya Babazono
    Department of Medicine, Diabetes Center, School of Medicine Tokyo Women's Medical University Tokyo Japan
  • Kazuhiko Tsuruya
    Department of Nephrology Nara Medical University Kashiwara Japan
  • Yukio Yuzawa
    Department of Nephrology Fujita Health University School of Medicine Toyoake Japan

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<jats:title>Abstract</jats:title><jats:p>Many reports have shown the therapeutic efficacy of LDL apheresis (LDL‐A) in drug‐resistant nephrotic syndrome (NS) for improvement of heavy proteinuria and severely impaired renal function. To obtain comprehensive results in a large number of cases, a post hoc analysis of the Prospective Observational survey on the Long‐Term Effects of the LDL‐Apheresis on the Drug Resistant Nephrotic Syndrome (POLARIS) study was performed by stratifying enrolled cases according to the pretreatment estimated glomerular filtration rate (eGFR) levels indicating normal (N) (≥60 ml/min/1.73 m<jats:sup>2</jats:sup>), moderately impaired (M) (≥30 to <60 ml/min/1.73 m<jats:sup>2</jats:sup>), and severely impaired (S) (<30 ml/min/1.73 m<jats:sup>2</jats:sup>) renal function. Significant improvements of proteinuria and renal function were found in Group N and, most interestingly, in Group M. A tendency for improvement in proteinuria was found in Group S. Most cases in all groups had not entered end‐stage renal disease at 2 years after LDL‐A treatment. These results suggest that LDL‐A has therapeutic efficacy even in cases in which renal function has declined to 30 ml/min/1.73 m<jats:sup>2</jats:sup>.</jats:p>

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