A New Monoterpene from the Rhizomes of <i>Alpinia galanga</i> and Its Anti‐Vpr Activity

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  • Nhat Nam Hoang
    Institute of Natural Medicine University of Toyama 2630-Sugitani Toyama 930-0194 Japan
  • Takeshi Kodama
    Institute of Natural Medicine University of Toyama 2630-Sugitani Toyama 930-0194 Japan
  • Nwet Nwet Win
    Institute of Natural Medicine University of Toyama 2630-Sugitani Toyama 930-0194 Japan
  • Prema
    Institute of Natural Medicine University of Toyama 2630-Sugitani Toyama 930-0194 Japan
  • Kiep Minh Do
    Institute of Natural Medicine University of Toyama 2630-Sugitani Toyama 930-0194 Japan
  • Ikuro Abe
    Graduate School of Pharmaceutical Sciences The University of Tokyo 7-3-1 Hongo Bunkyo-ku, Tokyo 113-0033 Japan
  • Hiroyuki Morita
    Institute of Natural Medicine University of Toyama 2630-Sugitani Toyama 930-0194 Japan

抄録

<jats:title>Abstract</jats:title><jats:p>A new menthane‐type monoterpene, alpigalanol (<jats:bold>1</jats:bold>), together with four known terpenes (<jats:bold>2</jats:bold>–<jats:bold>5</jats:bold>) were isolated from the ethyl acetate soluble fraction of the 70 % ethanol extract of the <jats:italic>Alpinia galanga</jats:italic> rhizomes. The structure of <jats:bold>1</jats:bold> was determined by spectroscopic analyses, including 1D‐ and 2D‐NMR. The extract of the <jats:italic>A. galanga</jats:italic> rhizomes and all isolated compounds (<jats:bold>1</jats:bold>–<jats:bold>5</jats:bold>) possessed Vpr inhibitory activities against the TREx‐HeLa‐Vpr cells at a concentration of 1.25 μM without showing any cytotoxicity.</jats:p>

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