Advanced Photosensitizer Activation Strategies for Smarter Photodynamic Therapy Beacons
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- Benjamin M. Luby
- Princess Margaret Cancer Centre and Techna Institute University Health Network 101 College St. Toronto ON Canada
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- Connor D. Walsh
- Princess Margaret Cancer Centre and Techna Institute University Health Network 101 College St. Toronto ON Canada
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- Gang Zheng
- Princess Margaret Cancer Centre and Techna Institute University Health Network 101 College St. Toronto ON Canada
説明
<jats:title>Abstract</jats:title><jats:p>Photodynamic therapy (PDT) is a clinical treatment in which a light‐absorbing drug called a photosensitizer (PS) is combined with light and molecular oxygen to generate cytotoxic singlet oxygen. PDT provides additional tissue selectivity compared to conventional chemotherapy as singlet oxygen is generated only in areas in which PS accumulates and that are simultaneously illuminated by a light source with sufficient irradiance and dose. Early PDT beacons built on this concept by adding an analyte‐responsive element that simultaneously turns on PDT and fluorescence, providing both an additional layer of selectivity and real‐time feedback of the PS′s activation state. More recent PDT beacons have expanded this idea, with new methods now available for sensing analytes, generating singlet oxygen, and reporting treatment status. In this Minireview, we consider developments in advanced activation strategies implemented in therapeutic and theranostic beacons.</jats:p>
収録刊行物
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- Angewandte Chemie International Edition
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Angewandte Chemie International Edition 58 (9), 2558-2569, 2018-12-28
Wiley