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- Nicola Solari
- Lendület Laboratory of Systems Neuroscience Department of Cellular and Network Neurobiology Institute of Experimental Medicine Hungarian Academy of Sciences Budapest Hungary
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- Balázs Hangya
- Lendület Laboratory of Systems Neuroscience Department of Cellular and Network Neurobiology Institute of Experimental Medicine Hungarian Academy of Sciences Budapest Hungary
抄録
<jats:title>Abstract</jats:title><jats:p>Spatial learning, including encoding and retrieval of spatial memories as well as holding spatial information in working memory generally serving navigation under a broad range of circumstances, relies on a network of structures. While central to this network are medial temporal lobe structures with a widely appreciated crucial function of the hippocampus, neocortical areas such as the posterior parietal cortex and the retrosplenial cortex also play essential roles. Since the hippocampus receives its main subcortical input from the medial septum of the basal forebrain (BF) cholinergic system, it is not surprising that the potential role of the septo‐hippocampal pathway in spatial navigation has been investigated in many studies. Much less is known of the involvement in spatial cognition of the parallel projection system linking the posterior BF with neocortical areas. Here we review the current state of the art of the division of labour within this complex ‘navigation system’, with special focus on how subcortical cholinergic inputs may regulate various aspects of spatial learning, memory and navigation.</jats:p>
収録刊行物
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- European Journal of Neuroscience
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European Journal of Neuroscience 48 (5), 2199-2230, 2018-08-19
Wiley