A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

DOI Web Site Web Site 6 Citations
  • Christina Krienke
    TRON – Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany.
  • Laura Kolb
    TRON – Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany.
  • Elif Diken
    TRON – Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany.
  • Michael Streuber
    TRON – Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany.
  • Sarah Kirchhoff
    TRON – Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany.
  • Thomas Bukur
    TRON – Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany.
  • Özlem Akilli-Öztürk
    TRON – Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany.
  • Lena M. Kranz
    Biopharmaceutical New Technologies (BioNTech) Corporation, An der Goldgrube 12, Mainz 55131, Germany.
  • Hendrik Berger
    Biopharmaceutical New Technologies (BioNTech) Corporation, An der Goldgrube 12, Mainz 55131, Germany.
  • Jutta Petschenka
    TRON – Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany.
  • Mustafa Diken
    TRON – Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany.
  • Sebastian Kreiter
    TRON – Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany.
  • Nir Yogev
    Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University, Mainz 55131, Germany.
  • Ari Waisman
    Research Center for Immunotherapy (FZI), University Medical Center at the Johannes Gutenberg University, Langenbeckstr. 1, Mainz 55131, Germany.
  • Katalin Karikó
    Biopharmaceutical New Technologies (BioNTech) Corporation, An der Goldgrube 12, Mainz 55131, Germany.
  • Özlem Türeci
    Biopharmaceutical New Technologies (BioNTech) Corporation, An der Goldgrube 12, Mainz 55131, Germany.
  • Ugur Sahin
    TRON – Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany.

Search this article

Description

<jats:title>Precision therapy for immune tolerance</jats:title> <jats:p> Autoimmune diseases, such as multiple sclerosis (MS), result from a breach of immunological self-tolerance and tissue damage by autoreactive T lymphocytes. Current treatments can cause systemic immune suppression and side effects such as increased risk of infections. Krienke <jats:italic>et al.</jats:italic> designed a messenger RNA vaccine strategy that lacks adjuvant activity and delivers MS autoantigens into lymphoid dendritic cells. This approach expands a distinct type of antigen-specific effector regulatory T cell that suppresses autoreactivity against targeted autoantigens and promotes bystander suppression of autoreactive T cells against other myelin-specific autoantigens. In mouse models of MS, the vaccine delayed the onset and reduced the severity of established disease without showing overt symptoms of general immune suppression. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6525" page="145" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.aay3638">145</jats:related-article> </jats:p>

Journal

  • Science

    Science 371 (6525), 145-153, 2021-01-08

    American Association for the Advancement of Science (AAAS)

Citations (6)*help

See more

Report a problem

Back to top