COVID-19-Associated Invasive Aspergillosis: Data from the UK National Mycology Reference Laboratory

  • Andrew M. Borman
    UK National Mycology Reference Laboratory, Public Health England South-West, Bristol, United Kingdom
  • Michael D. Palmer
    UK National Mycology Reference Laboratory, Public Health England South-West, Bristol, United Kingdom
  • Mark Fraser
    UK National Mycology Reference Laboratory, Public Health England South-West, Bristol, United Kingdom
  • Zoe Patterson
    UK National Mycology Reference Laboratory, Public Health England South-West, Bristol, United Kingdom
  • Ciara Mann
    UK National Mycology Reference Laboratory, Public Health England South-West, Bristol, United Kingdom
  • Debra Oliver
    UK National Mycology Reference Laboratory, Public Health England South-West, Bristol, United Kingdom
  • Christopher J. Linton
    UK National Mycology Reference Laboratory, Public Health England South-West, Bristol, United Kingdom
  • Martin Gough
    UK National Mycology Reference Laboratory, Public Health England South-West, Bristol, United Kingdom
  • Phillipa Brown
    UK National Mycology Reference Laboratory, Public Health England South-West, Bristol, United Kingdom
  • Agnieszka Dzietczyk
    UK National Mycology Reference Laboratory, Public Health England South-West, Bristol, United Kingdom
  • Michelle Hedley
    UK National Mycology Reference Laboratory, Public Health England South-West, Bristol, United Kingdom
  • Sue McLachlan
    UK National Mycology Reference Laboratory, Public Health England South-West, Bristol, United Kingdom
  • Julie King
    UK National Mycology Reference Laboratory, Public Health England South-West, Bristol, United Kingdom
  • Elizabeth M. Johnson
    UK National Mycology Reference Laboratory, Public Health England South-West, Bristol, United Kingdom

説明

<jats:p>COVID-19-associated pulmonary aspergillosis (CAPA) was recently reported as a potential infective complication affecting critically ill patients with acute respiratory distress syndrome following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, with incidence rates varying from 8 to 33% depending on the study. However, definitive diagnosis of CAPA is challenging. Standardized diagnostic algorithms and definitions are lacking, clinicians are reticent to perform aerosol-generating bronchoalveolar lavages for galactomannan testing and microscopic and cultural examination, and questions surround the diagnostic sensitivity of different serum biomarkers.</jats:p>

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