Broad and Differential Animal Angiotensin-Converting Enzyme 2 Receptor Usage by SARS-CoV-2
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- Xuesen Zhao
- Institute of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China
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- Danying Chen
- Institute of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China
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- Robert Szabla
- Department of Biochemistry, Western University, London, Ontario, Canada
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- Mei Zheng
- Institute of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China
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- Guoli Li
- Institute of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China
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- Pengcheng Du
- Institute of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China
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- Shuangli Zheng
- Institute of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China
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- Xinglin Li
- Institute of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China
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- Chuan Song
- Institute of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China
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- Rui Li
- Institute of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China
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- Ju-Tao Guo
- Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, Pennsylvania, USA
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- Murray Junop
- Department of Biochemistry, Western University, London, Ontario, Canada
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- Hui Zeng
- Institute of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China
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- Hanxin Lin
- Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada
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- Tom Gallagher
- editor
説明
<jats:p>SARS-CoV-2 uses human ACE2 as a primary receptor for host cell entry. Viral entry mediated by the interaction of ACE2 with spike protein largely determines host range and is the major constraint to interspecies transmission. We examined the receptor activity of 14 ACE2 orthologs and found that wild-type and mutant SARS-CoV-2 lacking the furin cleavage site in S protein could utilize ACE2 from a broad range of animal species to enter host cells. These results have important implications in the natural hosts, interspecies transmission, animal models, and molecular basis of receptor binding for SARS-CoV-2.</jats:p>
収録刊行物
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- Journal of Virology
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Journal of Virology 94 (18), e00940-20-, 2020-08-31
American Society for Microbiology
