CD3 bispecific antibody–induced cytokine release is dispensable for cytotoxic T cell activity

DOI Web Site 1 Citations
  • Ji Li
    Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Robert Piskol
    Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Ryan Ybarra
    Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Ying-Jiun J. Chen
    Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Jason Li
    Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Dionysos Slaga
    Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Maria Hristopoulos
    Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Robyn Clark
    Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Zora Modrusan
    Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Klara Totpal
    Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Melissa R. Junttila
    Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Teemu T. Junttila
    Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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<jats:p>Cytokine release induced by anti-HER2/CD3 is mediated by TNF-α and can be suppressed by blocking TNF-α, IL-6, or IL-1 without affecting efficacy.</jats:p>

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