An Innovative Hydrogen Peroxide‐Sensing Scaffold and Insight Towards its Potential as an ROS‐Activated Persulfide Donor

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  • Rynne A. Hankins
    Department of Chemistry Wake Forest University, Wake Downtown Campus Winston-Salem NC 27101 USA
  • S. Israel Suarez
    Department of Chemistry Wake Forest University, Wake Downtown Campus Winston-Salem NC 27101 USA
  • Madison A. Kalk
    Department of Chemistry Wake Forest University, Wake Downtown Campus Winston-Salem NC 27101 USA
  • Nolan M. Green
    Department of Chemistry Wake Forest University, Wake Downtown Campus Winston-Salem NC 27101 USA
  • Megan N. Harty
    Department of Chemistry Wake Forest University, Wake Downtown Campus Winston-Salem NC 27101 USA
  • John C. Lukesh
    Department of Chemistry Wake Forest University, Wake Downtown Campus Winston-Salem NC 27101 USA

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<jats:title>Abstract</jats:title><jats:p>Reactive sulfur species, such as hydrogen sulfide, persulfides, and polysulfides, have recently emerged as key signaling molecules and important physiological mediators within mammalian systems. To better assess the therapeutic potential of their exogenous administration, we report on the development of a unique hydrogen peroxide (H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>)‐sensing motif and its capacity for providing cellular protection against oxidative stress while serving as a reactive oxygen species (ROS)‐activated persulfide donor. With the strategic implementation of a <jats:italic>gem</jats:italic>‐dimethyl group to promote both stability and cyclization, we found the initial rate of payload release from this newly derived scaffold to be directly proportional to the concentration of H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> and to proceed via an unprecedented pathway that avoids the production of electrophilic byproducts, a severe limitation that has plagued the physiological application of previous designs.</jats:p>

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