Fibrin-associated diffuse large B-cell lymphoma with plasmacytic differentiation: case report and literature review
説明
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Primary cardiac lymphomas are extremely rare entities (< 2% of cardiac tumours) and the most frequent histologic type is diffuse large B-cell lymphoma (DLBCL). Fibrin-associated DLBCL (FA-DLBCL) is a very unusual form of DLBCL associated with chronic inflammation, and only case reports and small series have been described. In the heart, it usually occurs in the context of a cardiac myxoma or cardiac prostheses and it is not bulk forming. These lymphomas frequently present with non-germinal center phenotype and are associated with Epstein-Barr virus (EBV) type III latency.</jats:p> </jats:sec><jats:sec> <jats:title>Case presentation</jats:title> <jats:p>We describe a case of FA-DLBCL arising in a cardiac myxoma, with plasmacytic differentiation and type I EBV latency.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Although they are very rare, FA-DLBCLs should be known for their diagnostic difficulty, due to its unspecified clinical manifestations, and for their more favourable prognosis, sometimes even without additional treatment after surgical resection.</jats:p> </jats:sec>
収録刊行物
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- Diagnostic Pathology
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Diagnostic Pathology 15 (1), 117-, 2020-09-24
Springer Science and Business Media LLC
