-
- Vanessa Castelli
- Department of Life, Health and Environmental Sciences University of L'Aquila L'Aquila Italy
-
- Antonella Paladini
- Department of Life, Health and Environmental Sciences University of L'Aquila L'Aquila Italy
-
- Michele d’Angelo
- Department of Life, Health and Environmental Sciences University of L'Aquila L'Aquila Italy
-
- Marcello Allegretti
- Dompé Farmaceutici SpA L’Aquila Italy
-
- Flavio Mantelli
- Dompé Farmaceutici SpA L’Aquila Italy
-
- Laura Brandolini
- Dompé Farmaceutici SpA L’Aquila Italy
-
- Pasquale Cocchiaro
- Dompé Farmaceutici SpA L’Aquila Italy
-
- Annamaria Cimini
- Department of Life, Health and Environmental Sciences University of L'Aquila L'Aquila Italy
-
- Giustino Varrassi
- Paolo Procacci Foundation Roma Italy
説明
<jats:title>Abstract</jats:title><jats:p>Retinal disorders are leading causes of blindness and are due to an imbalance between reactive oxygen species and antioxidant scavenger (in favor of pro‐oxidant species) or a disruption of redox signaling and control. Indeed, it is well known that oxidative stress is one of the leading causes of retinal degenerative diseases. Different approaches using nutraceuticals resulted in protective effects in these disorders. This review will discuss the impact of oxidative stress in retinal neurodegenerative diseases and the potential strategies for avoiding or counteracting oxidative damage in retinal tissues, with a specific focus on taurine. Increasing data indicate that taurine may be effective in slowing down the progression of degenerative retinal diseases, thus suggesting that taurine can be a promising candidate for the prevention or as adjuvant treatment of these diseases. The mechanism by which taurine supplementation acts is mainly related to the reduction of oxidative stress. In particular, it has been demonstrated to improve retinal reduced glutathione, malondialdehyde, superoxide dismutase, and catalase activities. Antiapoptotic effects are also involved; however, the protective mechanisms exerted by taurine against retinal damage remain to be further investigated.</jats:p>
収録刊行物
-
- CNS Neuroscience & Therapeutics
-
CNS Neuroscience & Therapeutics 27 (4), 403-412, 2021-02-23
Wiley