Ado-trastuzumab emtansine (T-DM1) in HER2+ advanced breast cancer patients: does pretreatment with pertuzumab matter?
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- Alessandra Fabi
- Oncologia Medica 1, Istituto Nazionale Tumori ‘Regina Elena’, Roma, 00144, Italy
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- Diana Giannarelli
- Unità di Biostatistica, Istituto Nazionale Tumori ‘Regina Elena’, Roma, 00144, Italy
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- Luca Moscetti
- Oncologia Medica, Ospedale Modena, Modena, 41125, Italy
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- Daniele Santini
- Oncologia Medica, Campus Bio-medico Universitario, Roma, 00128, Italy
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- Alberto Zambelli
- Oncologia Medica, Ospedale Papa Giovanni XXIII, Bergamo, 24127, Italy
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- Michelino De Laurentiis
- Breast Unit, Istituto Pascale, Napoli, 80131, Italy
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- Michele Caruso
- Humanitas Centro Catanese di Oncologia, Catania, 95126, Italy
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- Daniele Generali
- Dipartimento Universitario Clinico di Scienze Mediche, Chirurgiche e della Salute, Università degli Studi di Trieste, 34127, Trieste, Italy
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- Enrichetta Valle
- Oncologia Medica, Ospedale Businco, Cagliari, 09121, Italy
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- Vita Leonardi
- Oncologia Medica, ARNAS Civico, Palermo, 90127 Italy
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- Katia Cannita
- Oncologia Medica Ospedale L'Aquila, L'Aquila, 67100, Italy
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- Grazia Arpino
- Oncologia Medica, Università Federico II, Napoli, 80138, Italy
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- Gianfranco Filippelli
- Oncologia PO di Paola, ASP di Cosenza, Cosenza, Italy
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- Gianluigi Ferretti
- Oncologia Medica 1, Istituto Nazionale Tumori ‘Regina Elena’, Roma, 00144, Italy
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- Marianna Giampaglia
- Oncologia Medica, Ospedale San Carlo, Potenza, 85100, Italy
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- Filippo Montemurro
- Investigative Clinical Oncology, Candiolo Cancer Institute-FPO, IRCCS, 10060 Candiolo, Torino, Italy
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- Cecilia Nisticò
- Oncologia Medica 1, Istituto Nazionale Tumori ‘Regina Elena’, Roma, 00144, Italy
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- Simona Gasparro
- Oncologia Medica 1, Istituto Nazionale Tumori ‘Regina Elena’, Roma, 00144, Italy
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- Francesco Cognetti
- Oncologia Medica 1, Istituto Nazionale Tumori ‘Regina Elena’, Roma, 00144, Italy
抄録
<jats:p> Aim: We evaluated the outcomes of patients treated with ado-trastuzumab emantasine (T-DM1) after first-line pertuzumab/trastuzumab, compared with those receiving a trastuzumab-only-based regimen. Patients & methods: Patients who received second-line T-DM1 after pertuzumab/trastuzumab (n = 34) were compared with those who received only trastuzumab (n = 73). Results: Overall response rate was 33.3% in patients with prior pertuzumab and 57.1% in the remaining subjects. Disease control rate was 47 and 43%, respectively, and the clinical benefit rate was 43.3 and 71.1%, respectively. Median progression-free survival was 5.0 and 11.0 months, respectively (hazard ratio: 2.02; 95% CI: 1.14–3.58; p = 0.01). Conclusion: Patients treated with T-DM1 who previously received pertuzumab present poorer clinical outcomes compared with those receiving a trastuzumab-only-based regimen in the first-line setting. </jats:p>
収録刊行物
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- Future Oncology
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Future Oncology 13 (30), 2791-2797, 2017-12
Future Medicine Ltd