Viral proteins recognized by different TLRs

DOI Web Site Web Site 2 Citations
  • Rui Zhou
    Department of Microbiology, Institute of Basic Medical Sciences Zunyi Medical University Zunyi China
  • Li Liu
    Department of Microbiology Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College Beijing China
  • Yu Wang
    Department of Microbiology, Institute of Basic Medical Sciences Zunyi Medical University Zunyi China

Description

<jats:title>Abstract</jats:title><jats:p>Virus invasion activates the host's innate immune response, inducing the production of numerous cytokines and interferons to eliminate pathogens. Except for viral DNA/RNA, viral proteins are also targets of pattern recognition receptors. Membrane‐bound receptors such as Toll‐like receptor (TLR)1, TLR2, TLR4, TLR6, and TLR10 relate to the recognition of viral proteins. Distinct TLRs perform both protective and detrimental roles for a specific virus. Here, we review viral proteins serving as pathogen‐associated molecular patterns and their corresponding TLRs. These viruses are all enveloped, including respiratory syncytial virus, hepatitis C virus, measles virus, herpesvirus human immunodeficiency virus, and coronavirus, and can encode proteins to activate innate immunity in a TLR‐dependent way. The TLR‐viral protein relationship plays an important role in innate immunity activation. A detailed understanding of their pathways contributes to a novel direction for vaccine development.</jats:p>

Journal

Citations (2)*help

See more

Report a problem

Back to top