Mechanisms for the Resolution of Organ Fibrosis

  • Jeffrey C. Horowitz
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan
  • Victor J. Thannickal
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama

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説明

<jats:p>Fibrosis is a dynamic process with the potential for reversibility and restoration of near-normal tissue architecture and organ function. Herein, we review mechanisms for resolution of organ fibrosis, in particular that involving the lung, with an emphasis on the critical roles of myofibroblast apoptosis and clearance of deposited matrix.</jats:p>

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  • Physiology

    Physiology 34 (1), 43-55, 2019-01-01

    American Physiological Society

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