DMSO as a Switchable Alkylating Agent in Heteroarene C−H Functionalization

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  • R. Aleyda Garza‐Sanchez
    Organisch-Chemisches Institut Westfälische Wilhelms-Universität Münster Corrensstrasse 40 48149 Münster Germany
  • Tuhin Patra
    Organisch-Chemisches Institut Westfälische Wilhelms-Universität Münster Corrensstrasse 40 48149 Münster Germany
  • Adrian Tlahuext‐Aca
    Organisch-Chemisches Institut Westfälische Wilhelms-Universität Münster Corrensstrasse 40 48149 Münster Germany
  • Felix Strieth‐Kalthoff
    Organisch-Chemisches Institut Westfälische Wilhelms-Universität Münster Corrensstrasse 40 48149 Münster Germany
  • Frank Glorius
    Organisch-Chemisches Institut Westfälische Wilhelms-Universität Münster Corrensstrasse 40 48149 Münster Germany

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<jats:title>Abstract</jats:title><jats:p>Herein, we report a novel strategy for the activation of DMSO to act as a versatile alkylating agent in heteroarene C−H functionalization. This direct, simple, and mild switch between methylation/trideuteromethylation and methylthiomethylation of heteroarenes was achieved under reagent‐controlled photoredox catalysis conditions. The proposed mechanism is supported by both experimental and computational studies.</jats:p>

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