Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia

Toni Grönroos, Artturi Mäkinen, Saara Laukkanen, Juha Mehtonen, Atte Nikkilä, Laura Oksa, Samuli Rounioja, Yanara Marincevic-Zuniga, Jessica Nordlund, Virva Pohjolainen, Timo Paavonen, Merja Heinäniemi, Olli Lohi

doi:10.1038/s41598-020-58970-z

Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia

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<jats:title>Abstract</jats:title><jats:p>Acute lymphoblastic leukemia is marked by aberrant transcriptional features that alter cell differentiation, self-renewal, and proliferative features. We sought to identify the transcription factors exhibiting altered and subtype-specific expression patterns in B-ALL and report here that SOX11, a developmental and neuronal transcription factor, is aberrantly expressed in the ETV6-RUNX1 and TCF3-PBX1 subtypes of acute B-cell leukemias. We show that a high expression of <jats:italic>SOX11</jats:italic> leads to alterations of gene expression that are typically associated with cell adhesion, migration, and differentiation. A high expression is associated with DNA hypomethylation at the <jats:italic>SOX11</jats:italic> locus and a favorable outcome. The results indicate that SOX11 expression marks a group of patients with good outcomes and thereby prompts further study of its use as a biomarker.</jats:p>