Effect of yoghurt containing Bifidobacterium lactis Bb12®on faecal excretion of secretory immunoglobulin A and human beta-defensin 2 in healthy adult volunteers
説明
<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Probiotics are used to provide health benefits. The present study tested the effect of a probiotic yoghurt on faecal output of beta-defensin and immunoglobulin A in a group of young healthy women eating a defined diet.</jats:p> </jats:sec> <jats:sec> <jats:title>Findings</jats:title> <jats:p>26 women aged 18-21 (median 19) years residing in a hostel were given 200 ml normal yoghurt every day for a week, followed by probiotic yoghurt containing <jats:italic>Bifidobacterium lactis</jats:italic> Bb12<jats:sup>®</jats:sup> (10<jats:sup>9</jats:sup> in 200 ml) for three weeks, followed again by normal yoghurt for four weeks. Stool samples were collected at 0, 4 and 8 weeks and assayed for immunoglobulin A and human beta-defensin-2 by ELISA. All participants tolerated both normal and probiotic yoghurt well. Human beta-defensin-2 levels in faeces were not altered during the course of the study. On the other hand, compared to the basal sample, faecal IgA increased during probiotic feeding (P = 0.0184) and returned to normal after cessation of probiotic yoghurt intake.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p> <jats:italic>Bifidobacterium lactis</jats:italic> Bb12<jats:sup>®</jats:sup> increased secretory IgA output in faeces. This property may explain the ability of probiotics to prevent gastrointestinal and lower respiratory tract infections.</jats:p> </jats:sec>
収録刊行物
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- Nutrition Journal
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Nutrition Journal 10 (1), 138-, 2011-12
Springer Science and Business Media LLC
