The potential role of mechanically sensitive ion channels in the physiology, injury, and repair of articular cartilage

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  • Bo-Yang Xu
    School of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China
  • Yu Jin
    School of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China
  • Xiao-Hui Ma
    School of Culture and Health Communication, Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China
  • Chi-Yu Wang
    Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, USA
  • Yi Guo
    School of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China
  • Dan Zhou
    School of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China

抄録

<jats:p> Biomechanical factors play an extremely important role in regulating the function of articular chondrocytes. Understanding the mechanical factors that drive chondrocyte biological responses is at the heart of our interpretation of cascade events leading to changes in articular cartilage osteoarthritis. The mechanism by which mechanical load is transduced into intracellular signals that can regulate chondrocyte gene expression remains largely unknown. The mechanically sensitive ion channel (MSC) may be one of its specific mechanisms. This review focuses on four ion channels involved in the mechanotransduction of chondrocytes, exploring their properties and the main factors that activate the associated pathways. The upstream and downstream potential relationships between the protein pathways were also explored. The specific biophysical mechanism of the chondrocyte mechanical microenvironment is becoming the focus of research. Elucidating the mechanotransduction mechanism of MSC is essential for the research of biophysical pathogenesis and targeted drugs in cartilage injury-related diseases. </jats:p>

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