Genetics of Atrial Fibrillation in 2020

DOI Web Site 1 Citations
  • Carolina Roselli
    From the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (C.R., P.T.E.)
  • Michiel Rienstra
    Department of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (C.R., M.R.)
  • Patrick T. Ellinor
    From the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (C.R., P.T.E.)

Bibliographic Information

Other Title
  • GWAS, Genome Sequencing, Polygenic Risk, and Beyond

Description

<jats:p>Atrial fibrillation is a common heart rhythm disorder that leads to an increased risk for stroke and heart failure. Atrial fibrillation is a complex disease with both environmental and genetic risk factors that contribute to the arrhythmia. Over the last decade, rapid progress has been made in identifying the genetic basis for this common condition. In this review, we provide an overview of the primary types of genetic analyses performed for atrial fibrillation, including linkage studies, genome-wide association studies, and studies of rare coding variation. With these results in mind, we aim to highlighting the existing knowledge gaps and future directions for atrial fibrillation genetics research.</jats:p>

Journal

  • Circulation Research

    Circulation Research 127 (1), 21-33, 2020-06-19

    Ovid Technologies (Wolters Kluwer Health)

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