Prognostic Role of Hypertriglyceridemia in Patients With Stroke of Atherothrombotic Origin
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- Takao Hoshino
- From the Department of Neurology, Tokyo Women's Medical University Hospital, Japan.
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- Kentaro Ishizuka
- From the Department of Neurology, Tokyo Women's Medical University Hospital, Japan.
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- Sono Toi
- From the Department of Neurology, Tokyo Women's Medical University Hospital, Japan.
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- Takafumi Mizuno
- From the Department of Neurology, Tokyo Women's Medical University Hospital, Japan.
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- Ayako Nishimura
- From the Department of Neurology, Tokyo Women's Medical University Hospital, Japan.
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- Sho Wako
- From the Department of Neurology, Tokyo Women's Medical University Hospital, Japan.
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- Shuntaro Takahashi
- From the Department of Neurology, Tokyo Women's Medical University Hospital, Japan.
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- Kazuo Kitagawa
- From the Department of Neurology, Tokyo Women's Medical University Hospital, Japan.
説明
Hypertriglyceridemia is perceived to promote atherosclerotic pathology, but its role in stroke has not been well defined. Our aim was to assess the contribution of hypertriglyceridemia to residual vascular risk in patients with atherothrombotic stroke.The Tokyo Women's Medical University Stroke Registry is an ongoing prospective, observational registry in which 870 patients with acute ischemic stroke or TIA within 1 week of onset were consecutively enrolled and followed up for 1 year. Hypertriglyceridemia was defined as serum triglycerides levels of ≥150 mg/dL under fasting conditions. Significant stenosis of the cervicocephalic arteries was defined as having ≥50% stenosis or occlusion. The primary outcome was major adverse cardiovascular events, including nonfatal stroke, nonfatal acute coronary syndrome, and vascular death.Of 870 patients (mean age 70.1 years, male 60.9%), 217 (24.9%) had hypertriglyceridemia. High triglycerides levels were significantly associated with an increased prevalence of intracranial artery stenosis, particularly in the anterior circulation, rather than extracranial artery stenosis. Patients with hypertriglyceridemia had a greater risk of major adverse cardiovascular events than those without (annual rate 20.9% vs 9.7%;Hypertriglyceridemia is an important modifiable risk factor that drives residual vascular risk in patients with stroke of atherothrombotic origin, even while on statin therapy.UMIN000031913 at upload.umin.ac.jp.This study provides Class I evidence that in patients with atherothrombotic stroke, hypertriglyceridemia is associated with an increased risk of major cardiovascular events.
収録刊行物
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- Neurology
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Neurology 98 (16), 2022-04-19
Ovid Technologies (Wolters Kluwer Health)
