A DIFFERENCE IN MORTALITY RATE AND INCIDENCE OF KERNICTERUS AMONG PREMATURE INFANTS ALLOTTED TO TWO PROPHYLACTIC ANTIBACTERIAL REGIMENS

DOI PDF 1 Citations
  • William A. Silverman
    Babies Hospital, and Department of Pediatrics, Columbia University, College of Physicians and Surgeons
  • Dorothy H. Andersen
    Babies Hospital, and Department of Pediatrics, Columbia University, College of Physicians and Surgeons
  • William A. Blanc
    Babies Hospital, and Department of Pediatrics, Columbia University, College of Physicians and Surgeons
  • Douglas N. Crozier
    Babies Hospital, and Department of Pediatrics, Columbia University, College of Physicians and Surgeons

Abstract

<jats:p>A controlled clinical trial was designed to test the relative effectiveness of two prophylactic antibacterial regimens administered to premature infants in the first 5 days of life. Infants who received penicillin/sulfisoxazole (diethanolamine) died at a significantly higher rate than those who received oxytetracycline. The incidence of kernicterus was significantly higher among infants who received penicillin/sulfisoxazole (diethanolamine).</jats:p>

Journal

  • Pediatrics

    Pediatrics 18 (4), 614-625, 1956-10-01

    American Academy of Pediatrics (AAP)

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