Life-Sparing Effect of Human Cord Blood-Mesenchymal Stem Cells in Experimental Acute Kidney Injury
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- Marina Morigi
- “Mario Negri” Institute for Pharmacological Research, Bergamo, Italy
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- Cinzia Rota
- “Mario Negri” Institute for Pharmacological Research, Bergamo, Italy
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- Tiziana Montemurro
- Cell Factory, Centro di Medicina Trasfusionale, Terapia Cellulare e Criobiologia, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
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- Elisa Montelatici
- Cell Factory, Centro di Medicina Trasfusionale, Terapia Cellulare e Criobiologia, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
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- Viviana Lo Cicero
- Cell Factory, Centro di Medicina Trasfusionale, Terapia Cellulare e Criobiologia, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
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- Barbara Imberti
- “Mario Negri” Institute for Pharmacological Research, Bergamo, Italy
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- Mauro Abbate
- “Mario Negri” Institute for Pharmacological Research, Bergamo, Italy
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- Carla Zoja
- “Mario Negri” Institute for Pharmacological Research, Bergamo, Italy
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- Paola Cassis
- “Mario Negri” Institute for Pharmacological Research, Bergamo, Italy
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- Lorena Longaretti
- “Mario Negri” Institute for Pharmacological Research, Bergamo, Italy
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- Paolo Rebulla
- Cell Factory, Centro di Medicina Trasfusionale, Terapia Cellulare e Criobiologia, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
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- Martino Introna
- Laboratory of Cell Therapy “G. Lanzani,” Ospedali Riuniti di Bergamo, Bergamo, ItalyUnit of Hematology and Unit of Nephrology and Dialysis, Azienda Ospedaliera, Ospedali Riuniti di Bergamo, Bergamo, Italy
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- Chiara Capelli
- Laboratory of Cell Therapy “G. Lanzani,” Ospedali Riuniti di Bergamo, Bergamo, ItalyUnit of Hematology and Unit of Nephrology and Dialysis, Azienda Ospedaliera, Ospedali Riuniti di Bergamo, Bergamo, Italy
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- Ariela Benigni
- “Mario Negri” Institute for Pharmacological Research, Bergamo, Italy
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- Giuseppe Remuzzi
- “Mario Negri” Institute for Pharmacological Research, Bergamo, Italy
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- Lorenza Lazzari
- Cell Factory, Centro di Medicina Trasfusionale, Terapia Cellulare e Criobiologia, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
Description
<jats:title>Abstract</jats:title><jats:p>In search for new sources of mesenchymal stem cells (MSCs) for renal repair in acute kidney injury (AKI), we investigated the potential of human cord blood (CB)-MSCs to cure mice with AKI. Infusion of CB-MSCs in immunodeficient mice with cisplatin-induced AKI ameliorated both renal function and tubular cell injury, and prolonged survival. Transplanted CB-MSCs localized in peritubular areas, limited capillary alterations and neutrophil infiltration. Apoptosis reduced and tubular cell proliferation increased by virtue of stem cell capacity to produce growth factors. The reno-protective effect of CB-MSCs was further confirmed by their ability to inhibit oxidative damage and to induce the prosurvival factor Akt in tubular cells. The evidence that CB-MSCs in vitro increased the production of growth factors and inhibited IL-1β and TNFα synthesis when cocultured with damaged proximal tubular cells indicates a regenerative and anti-inflammatory action of stem cell treatment. Altogether these results highlight the potential of human CB-MSCs as future cell therapy for testing in human AKI.</jats:p>
Journal
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- Stem Cells
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Stem Cells 28 (3), 513-522, 2010-01-04
Oxford University Press (OUP)
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Details 詳細情報について
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- CRID
- 1360579817598939776
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- DOI
- 10.1002/stem.293
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- ISSN
- 15494918
- 10665099
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- Data Source
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- Crossref