Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure

James J. McNamee, Michael A. Gillies, Nicholas A. Barrett, Gavin D. Perkins, William Tunnicliffe, Duncan Young, Andrew Bentley, David A. Harrison, Daniel Brodie, Andrew J. Boyle, Jonathan E. Millar, Tamas Szakmany, Jonathan Bannard-Smith, Redmond P. Tully, Ashley Agus, Clíona McDowell, Colette Jackson, Daniel F. McAuley, Temi Adedoyin, Kayode Adeniji, Caroline Aherne, Gopal Anand Iyer, Prematie Andreou, Gillian Andrew, Ian Angus, Gill Arbane, Pauline Austin, Karen Austin, Georg Auzinger, Jonathan Ball, Dorota Banach, Leona Bannon, Lucy Barclay, Helena Barcraft-Barnes, Richard Beale, Sarah Bean, Georgia Bercades, Colin Bergin, Sian Bhardwaj, Colin Bigham, Isobel Birkinshaw, Euan Black, Aneta Bociek, Andrew Bodenham, Malcolm G Booth, Christine Bowyer, David A Brealey, Stephen Brett, Jennifer Brooks, Karen Burt, Louise Cabrelli, Leilani Cabreros, Hazel Cahill, Aidan Campbell, Luigi Camporota, Sara Campos, Julie Camsooksai, Ronald Carrera, Joseph Carter, Jaime Carungcong, Anelise Catelan-Zborowski, Susanne Cathcart, Shreekant Champanerkar, Matthew Charlton, Shiney Cherian, Linsey Christie, Srikanth Chukkambotla, Amy Clark, Sarah Clark, Richard Clark, Ian Clement, Eve Cocks, Stephen Cole, Sonia Cole, Jade Cole, Nick Coleman, Emma Connaughton, Andrew Conway Morris, Lauren Cooper, Ian Cooper, Carolyn Corbett, Sarah Cornell, Carmen Correia, Victoria Cottam, Keith Couper, Laura Creighton, Maryam Crews, Neil Crooks, Jacqueline Curtin, Zoe Daly, Alan Davidson, Rhys Davies, Michelle Davies, Christopher Day, Mike Dean, Ged Dempsey, Anna Dennis, Susan Dermody, Liesl Despy, Murugesh Devaramani, Patricia Doble, Robert Docking, Adrian Donnelly, Natalie Dooley, Natalie Dormand, Andrew Drummond, Mark JG Dunn, Leigh Dunn, Christine Eastgate, Karen Ellis, Sarah Farnell, Helen Farrah, Emma Fellows, Timothy Felton, Helder Filipe, Clare Finney, Simon Finney, Jillian Fitchett, Brian Gammon, Saibal Ganguly, Minerva Gellamucho, Susan Gibson, Charles Gibson, Lynn Gilfeather, Michael A Gillies, Stuart Gillon, Shameer Gopal, Anthony Gordon, Stephanie Goundry, Lia Grainger, Neus Grau Novellas, Joanne Gresty, Mark Griffiths, Jamie Gross, Una Gunter, Karen Hallett, Samantha Harkett, Donna Harrison-Briggs, Louise Hartley, Ingrid Hass, Noel Hemmings, Steven Henderson, Helen Hill, Gemma Hodkinson, Kate Howard, Clare Howcroft, Ying Hu, Jonathan Hulme, Tariq Husain, Joanne Hutter, Dorothy Ilano, Richard Innes, Nicola Jacques, Sarah James, Sarah Jenkins, Paul Johnston, Brian Johnston, Colette Jones-Criddle, Santhana Kannan, Parminder Kaur Bhuie, Andrea Kelly, Sophie Kennedy-Hay, Liana Lankester, Susannah Leaver, Stephane Ledot, Rosario Lim, Lucie Linhartova, Fei Long, Niall S MacCallum, Sarah MacGill, Andrew Mackay, Sarah Maclean, Amber Markham, Daniel Martin, Tim Martin, Tracy Mason, Nick Mason, Justine McCann, Corrienne McCulloch, Christopher McGhee, Loren McGinley-Keag, Michael McLaughlin, Lia McNamee, Margaret McNeil, Laura Mee, Claire Mellis, Teresa Melody, Jeanette Mills, Esther Molina, Matt PG Morgan, Mushiya Mpelembue, Stephanie Muldoon, Sheila Munt, Nazril Nordin, Christopher Nutt, Sinead O'Kane, Aisling O'Neill, Valerie Page, Elankumaran Paramasivam, Dhruv Parekh, Sarah Patch, Sameer Patel, Lia Paton, Gavin Perkins, Manuel Pinto, David Pogson, Petra Polgarova, Jagtar Pooni, Martin Pope, Grant C Price, Jashmin Priya Maria, Lynda Purdy, Alex Puxty, John Rae, Mark Raper, Henrik Reschreiter, Steve Rose, Anthony Rostron, Alistair Roy, Christine Ryan, Jung Ryu, Kiran Salaunkey, Julia Sampson, Vivian Sathianathan, Lorraine Scaife, Simon WM Scott, Timothy E Scott, Sumant Shanbhag, David Shaw, Malcolm Sim, Suveer Singh, Andrew Smallwood, Hazel Smith, John Smith, Jayne Smith, Deborah Smyth, Catherine Snelson, Michael Spivey, Elaine Spruce, Charlotte Summers, Peter Sutton, Nicholas Talbot, Maie Templeton, Jessica Thrush, Redmond Tully, Ian Turner-Bone, Tonny Veenith, Alan Vuylsteke, Andrew Walden, Jonathan Walker, Kathryn Ward, Tim Walsh, Victoria Waugh, Colin Wells, Ingeborg Welters, Tony Whitehouse, Arlo Whitehouse, Christopher Whitton, Elizabeth Wilby, Danielle Wilcox, Laura Wilding, James Williams, Karen Williams, Sarah Winnard, Lindsey Woods, Chris Wright, Neil H Young, Xiaobei Zhao, Parjam Zolfaghari

doi:10.1001/jama.2021.13374

Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure

DOI PDF 2 Citations

James J. McNamee

Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Science, Queen’s University Belfast, Belfast, United Kingdom
Michael A. Gillies

Department of Anaesthesia, Critical Care and Pain Medicine, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
Nicholas A. Barrett

Guy’s and St Thomas’ NHS Foundation Trust, King’s College London, United Kingdom
Gavin D. Perkins

Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, United Kingdom
William Tunnicliffe

University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
Duncan Young

Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, United Kingdom
Andrew Bentley

Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom
David A. Harrison

Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), London, United Kingdom
Daniel Brodie

Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York
Andrew J. Boyle

Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Science, Queen’s University Belfast, Belfast, United Kingdom
Jonathan E. Millar

Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom
Tamas Szakmany

Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University, Cardiff, United Kingdom
Jonathan Bannard-Smith

Department of Critical Care, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom
Redmond P. Tully

Department of Anaesthetics and Intensive Care, Royal Oldham Hospital, Northern Care Alliance, Oldham, United Kingdom
Ashley Agus

Northern Ireland Clinical Trials Unit, Belfast, United Kingdom
Clíona McDowell

Northern Ireland Clinical Trials Unit, Belfast, United Kingdom
Colette Jackson

Northern Ireland Clinical Trials Unit, Belfast, United Kingdom
Daniel F. McAuley

Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Science, Queen’s University Belfast, Belfast, United Kingdom
Temi Adedoyin

for the REST Investigators
Kayode Adeniji

for the REST Investigators
Caroline Aherne

for the REST Investigators
Gopal Anand Iyer

for the REST Investigators
Prematie Andreou

for the REST Investigators
Gillian Andrew

for the REST Investigators
Ian Angus

for the REST Investigators
Gill Arbane

for the REST Investigators
Pauline Austin

for the REST Investigators
Karen Austin

for the REST Investigators
Georg Auzinger

for the REST Investigators
Jonathan Ball

for the REST Investigators
Dorota Banach

for the REST Investigators
Leona Bannon

for the REST Investigators
Lucy Barclay

for the REST Investigators
Helena Barcraft-Barnes

for the REST Investigators
Richard Beale

for the REST Investigators
Sarah Bean

for the REST Investigators
Georgia Bercades

for the REST Investigators
Colin Bergin

for the REST Investigators
Sian Bhardwaj

for the REST Investigators
Colin Bigham

for the REST Investigators
Isobel Birkinshaw

for the REST Investigators
Euan Black

for the REST Investigators
Aneta Bociek

for the REST Investigators
Andrew Bodenham

for the REST Investigators
Malcolm G Booth

for the REST Investigators
Christine Bowyer

for the REST Investigators
David A Brealey

for the REST Investigators
Stephen Brett

for the REST Investigators
Jennifer Brooks

for the REST Investigators
Karen Burt

for the REST Investigators
Louise Cabrelli

for the REST Investigators
Leilani Cabreros

for the REST Investigators
Hazel Cahill

for the REST Investigators
Aidan Campbell

for the REST Investigators
Luigi Camporota

for the REST Investigators
Sara Campos

for the REST Investigators
Julie Camsooksai

for the REST Investigators
Ronald Carrera

for the REST Investigators
Joseph Carter

for the REST Investigators
Jaime Carungcong

for the REST Investigators
Anelise Catelan-Zborowski

for the REST Investigators
Susanne Cathcart

for the REST Investigators
Shreekant Champanerkar

for the REST Investigators
Matthew Charlton

for the REST Investigators
Shiney Cherian

for the REST Investigators
Linsey Christie

for the REST Investigators
Srikanth Chukkambotla

for the REST Investigators
Amy Clark

for the REST Investigators
Sarah Clark

for the REST Investigators
Richard Clark

for the REST Investigators
Ian Clement

for the REST Investigators
Eve Cocks

for the REST Investigators
Stephen Cole

for the REST Investigators
Sonia Cole

for the REST Investigators
Jade Cole

for the REST Investigators
Nick Coleman

for the REST Investigators
Emma Connaughton

for the REST Investigators
Andrew Conway Morris

for the REST Investigators
Lauren Cooper

for the REST Investigators
Ian Cooper

for the REST Investigators
Carolyn Corbett

for the REST Investigators
Sarah Cornell

for the REST Investigators
Carmen Correia

for the REST Investigators
Victoria Cottam

for the REST Investigators
Keith Couper

for the REST Investigators
Laura Creighton

for the REST Investigators
Maryam Crews

for the REST Investigators
Neil Crooks

for the REST Investigators
Jacqueline Curtin

for the REST Investigators
Zoe Daly

for the REST Investigators
Alan Davidson

for the REST Investigators
Rhys Davies

for the REST Investigators
Michelle Davies

for the REST Investigators
Christopher Day

for the REST Investigators
Mike Dean

for the REST Investigators
Ged Dempsey

for the REST Investigators
Anna Dennis

for the REST Investigators
Susan Dermody

for the REST Investigators
Liesl Despy

for the REST Investigators
Murugesh Devaramani

for the REST Investigators
Patricia Doble

for the REST Investigators
Robert Docking

for the REST Investigators
Adrian Donnelly

for the REST Investigators
Natalie Dooley

for the REST Investigators
Natalie Dormand

for the REST Investigators
Andrew Drummond

for the REST Investigators
Mark JG Dunn

for the REST Investigators
Leigh Dunn

for the REST Investigators
Christine Eastgate

for the REST Investigators
Karen Ellis

for the REST Investigators
Sarah Farnell

for the REST Investigators
Helen Farrah

for the REST Investigators
Emma Fellows

for the REST Investigators
Timothy Felton

for the REST Investigators
Helder Filipe

for the REST Investigators
Clare Finney

for the REST Investigators
Simon Finney

for the REST Investigators
Jillian Fitchett

for the REST Investigators
Brian Gammon

for the REST Investigators
Saibal Ganguly

for the REST Investigators
Minerva Gellamucho

for the REST Investigators
Susan Gibson

for the REST Investigators
Charles Gibson

for the REST Investigators
Lynn Gilfeather

for the REST Investigators
Michael A Gillies

for the REST Investigators
Stuart Gillon

for the REST Investigators
Shameer Gopal

for the REST Investigators
Anthony Gordon

for the REST Investigators
Stephanie Goundry

for the REST Investigators
Lia Grainger

for the REST Investigators
Neus Grau Novellas

for the REST Investigators
Joanne Gresty

for the REST Investigators
Mark Griffiths

for the REST Investigators
Jamie Gross

for the REST Investigators
Una Gunter

for the REST Investigators
Karen Hallett

for the REST Investigators
Samantha Harkett

for the REST Investigators
Donna Harrison-Briggs

for the REST Investigators
Louise Hartley

for the REST Investigators
Ingrid Hass

for the REST Investigators
Noel Hemmings

for the REST Investigators
Steven Henderson

for the REST Investigators
Helen Hill

for the REST Investigators
Gemma Hodkinson

for the REST Investigators
Kate Howard

for the REST Investigators
Clare Howcroft

for the REST Investigators
Ying Hu

for the REST Investigators
Jonathan Hulme

for the REST Investigators
Tariq Husain

for the REST Investigators
Joanne Hutter

for the REST Investigators
Dorothy Ilano

for the REST Investigators
Richard Innes

for the REST Investigators
Nicola Jacques

for the REST Investigators
Sarah James

for the REST Investigators
Sarah Jenkins

for the REST Investigators
Paul Johnston

for the REST Investigators
Brian Johnston

for the REST Investigators
Colette Jones-Criddle

for the REST Investigators
Santhana Kannan

for the REST Investigators
Parminder Kaur Bhuie

for the REST Investigators
Andrea Kelly

for the REST Investigators
Sophie Kennedy-Hay

for the REST Investigators
Liana Lankester

for the REST Investigators
Susannah Leaver

for the REST Investigators
Stephane Ledot

for the REST Investigators
Rosario Lim

for the REST Investigators
Lucie Linhartova

for the REST Investigators
Fei Long

for the REST Investigators
Niall S MacCallum

for the REST Investigators
Sarah MacGill

for the REST Investigators
Andrew Mackay

for the REST Investigators
Sarah Maclean

for the REST Investigators
Amber Markham

for the REST Investigators
Daniel Martin

for the REST Investigators
Tim Martin

for the REST Investigators
Tracy Mason

for the REST Investigators
Nick Mason

for the REST Investigators
Justine McCann

for the REST Investigators
Corrienne McCulloch

for the REST Investigators
Christopher McGhee

for the REST Investigators
Loren McGinley-Keag

for the REST Investigators
Michael McLaughlin

for the REST Investigators
Lia McNamee

for the REST Investigators
Margaret McNeil

for the REST Investigators
Laura Mee

for the REST Investigators
Claire Mellis

for the REST Investigators
Teresa Melody

for the REST Investigators
Jeanette Mills

for the REST Investigators
Esther Molina

for the REST Investigators
Matt PG Morgan

for the REST Investigators
Mushiya Mpelembue

for the REST Investigators
Stephanie Muldoon

for the REST Investigators
Sheila Munt

for the REST Investigators
Nazril Nordin

for the REST Investigators
Christopher Nutt

for the REST Investigators
Sinead O'Kane

for the REST Investigators
Aisling O'Neill

for the REST Investigators
Valerie Page

for the REST Investigators
Elankumaran Paramasivam

for the REST Investigators
Dhruv Parekh

for the REST Investigators
Sarah Patch

for the REST Investigators
Sameer Patel

for the REST Investigators
Lia Paton

for the REST Investigators
Gavin Perkins

for the REST Investigators
Manuel Pinto

for the REST Investigators
David Pogson

for the REST Investigators
Petra Polgarova

for the REST Investigators
Jagtar Pooni

for the REST Investigators
Martin Pope

for the REST Investigators
Grant C Price

for the REST Investigators
Jashmin Priya Maria

for the REST Investigators
Lynda Purdy

for the REST Investigators
Alex Puxty

for the REST Investigators
John Rae

for the REST Investigators
Mark Raper

for the REST Investigators
Henrik Reschreiter

for the REST Investigators
Steve Rose

for the REST Investigators
Anthony Rostron

for the REST Investigators
Alistair Roy

for the REST Investigators
Christine Ryan

for the REST Investigators
Jung Ryu

for the REST Investigators
Kiran Salaunkey

for the REST Investigators
Julia Sampson

for the REST Investigators
Vivian Sathianathan

for the REST Investigators
Lorraine Scaife

for the REST Investigators
Simon WM Scott

for the REST Investigators
Timothy E Scott

for the REST Investigators
Sumant Shanbhag

for the REST Investigators
David Shaw

for the REST Investigators
Malcolm Sim

for the REST Investigators
Suveer Singh

for the REST Investigators
Andrew Smallwood

for the REST Investigators
Hazel Smith

for the REST Investigators
John Smith

for the REST Investigators
Jayne Smith

for the REST Investigators
Deborah Smyth

for the REST Investigators
Catherine Snelson

for the REST Investigators
Michael Spivey

for the REST Investigators
Elaine Spruce

for the REST Investigators
Charlotte Summers

for the REST Investigators
Peter Sutton

for the REST Investigators
Nicholas Talbot

for the REST Investigators
Maie Templeton

for the REST Investigators
Jessica Thrush

for the REST Investigators
Redmond Tully

for the REST Investigators
Ian Turner-Bone

for the REST Investigators
Tonny Veenith

for the REST Investigators
Alan Vuylsteke

for the REST Investigators
Andrew Walden

for the REST Investigators
Jonathan Walker

for the REST Investigators
Kathryn Ward

for the REST Investigators
Tim Walsh

for the REST Investigators
Victoria Waugh

for the REST Investigators
Colin Wells

for the REST Investigators
Ingeborg Welters

for the REST Investigators
Tony Whitehouse

for the REST Investigators
Arlo Whitehouse

for the REST Investigators
Christopher Whitton

for the REST Investigators
Elizabeth Wilby

for the REST Investigators
Danielle Wilcox

for the REST Investigators
Laura Wilding

for the REST Investigators
James Williams

for the REST Investigators
Karen Williams

for the REST Investigators
Sarah Winnard

for the REST Investigators
Lindsey Woods

for the REST Investigators
Chris Wright

for the REST Investigators
Neil H Young

for the REST Investigators
Xiaobei Zhao

for the REST Investigators
Parjam Zolfaghari

for the REST Investigators

Bibliographic Information

Other Title

The REST Randomized Clinical Trial

Journal

JAMA

JAMA 326 (11), 1013-, 2021-09-21

American Medical Association (AMA)

Citations (2)*help

Details 詳細情報について

CRID

1360579818084057344
DOI

10.1001/jama.2021.13374
ISSN

00987484
Web Site

https://jamanetwork.com/journals/jama/articlepdf/2783809/jama_mcnamee_2021_oi_210098_1639506462.73056.pdf
Data Source
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