Histological validation of cardiac magnetic resonance <i>T</i><sub>1</sub> mapping for detecting diffuse myocardial fibrosis in diabetic rabbits
-
- Mu Zeng
- Department of Radiology Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease Beijing China
-
- Nan Zhang
- Department of Radiology Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease Beijing China
-
- Yi He
- Department of Radiology Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease Beijing China
-
- Zhaoying Wen
- Department of Radiology Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease Beijing China
-
- Zhanhong Wang
- Department of Radiology Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease Beijing China
-
- Yike Zhao
- Department of Radiology Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease Beijing China
-
- Andreas Greiser
- Siemens AG Healthcare Sector Erlangen Germany
-
- Jing An
- MR Collaborations NE Asia Siemens Healthcare Beijing China
-
- Tianjing Zhang
- MR Collaborations NE Asia Siemens Healthcare Beijing China
-
- Bin Jing
- School of Biomedical Engineering, Capital Medical University Beijing China
-
- Xin Zhang
- National Key Laboratory of Biochemical Engineering Institute of Process Engineering, Chinese Academy of Sciences Beijing China
-
- Zhanming Fan
- Department of Radiology Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease Beijing China
-
- Debiao Li
- Biomedical Imaging Research Institute, Cedars‐Sinai Medical Center Los Angeles California USA
説明
<jats:sec><jats:title>Purpose</jats:title><jats:p>To pathologically verify the correlation between native <jats:italic>T</jats:italic><jats:sub>1</jats:sub> mapping, postcontrast <jats:italic>T</jats:italic><jats:sub>1</jats:sub> mapping, and extracellular volume fraction (ECV) and myocardial diffuse fibrosis, as determined by collagen volume fraction (CVF).</jats:p></jats:sec><jats:sec><jats:title>Materials and Methods</jats:title><jats:p>Thirty New Zealand white rabbits were randomly divided into the control group (<jats:italic>n</jats:italic> = 6), diabetes 3 months group (<jats:italic>n</jats:italic> = 8), diabetes 6 months group (<jats:italic>n</jats:italic> = 8), and diabetes 9 months group (<jats:italic>n</jats:italic> = 8). All the rabbits underwent clinical 3.0T magnetic resonance (MR) examinations with pre‐ and postcontrast modified Look–Locker inversion recovery <jats:italic>T</jats:italic><jats:sub>1</jats:sub> mapping. For the histological study, each rabbit was sacrificed after MR scanning, hematoxylin and eosin and Masson staining of the left ventricular myocardium were performed, and CVF was calculated. Pre‐ and postcontrast <jats:italic>T</jats:italic><jats:sub>1</jats:sub> values and ECV were compared to CVF using Pearson's correlation coefficients.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Two rabbits died in each diabetes group, thus each group included six rabbits. ECV calculated from pre‐ and postcontrast <jats:italic>T</jats:italic><jats:sub>1</jats:sub> values showed a very strong correlation with CVF (<jats:italic>r</jats:italic> = 0.876, <jats:italic>P</jats:italic> < 0.001), whereas postcontrast <jats:italic>T</jats:italic><jats:sub>1</jats:sub> values exhibited a moderate correlation with CVF (<jats:italic>r</jats:italic> = –0.564, <jats:italic>P</jats:italic> = 0.004). In contrast, precontrast <jats:italic>T</jats:italic><jats:sub>1</jats:sub> values showed no correlation with CVF (<jats:italic>r</jats:italic> = 0.311, <jats:italic>P</jats:italic> = 0.139).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>ECV has a very strong correlation with pathological CVF, and can be used to assess the degree of diffuse myocardial fibrosis better than the postcontrast <jats:italic>T</jats:italic><jats:sub>1</jats:sub> value. Precontrast <jats:italic>T</jats:italic><jats:sub>1</jats:sub> value has no significant correlation with diffuse myocardial fibrosis. J. Magn. Reson. Imaging 2016;44:1179–1185.</jats:p></jats:sec>
収録刊行物
-
- Journal of Magnetic Resonance Imaging
-
Journal of Magnetic Resonance Imaging 44 (5), 1179-1185, 2016-04-09
Wiley