抄録
<jats:p>The <jats:italic>NF2</jats:italic> tumor suppressor gene is a frequent somatically mutated gene in mesothelioma, with 30%–40% mesotheliomas showing <jats:italic>NF2</jats:italic> inactivation. <jats:italic>NF2</jats:italic> encodes merlin, a member of the ezrin, radixin, and moesin (ERM) family of proteins that regulate cytoskeleton and cell signaling. Recent genome analysis revealed that <jats:italic>NF2</jats:italic> alteration may be a late event in mesothelioma development, suggesting that <jats:italic>NF2</jats:italic> mutation confers a more aggressive phenotype to mesothelioma cells and may not be directly caused by asbestos exposure. The Hippo tumor-suppressive and mTOR prooncogenic signaling pathways are crucial cell-signaling cascades regulated by merlin. Although the exact role and timing of <jats:italic>NF2</jats:italic> inactivation in mesothelioma cells remain to be elucidated, targeting the <jats:italic>NF2</jats:italic>/merlin-Hippo pathway may be a new therapeutic strategy for patients with mesothelioma.</jats:p>
収録刊行物
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- Frontiers in Toxicology
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Frontiers in Toxicology 5 2023-04-25
Frontiers Media SA