Blood Pressure and Risk of Cardiovascular Disease in UK Biobank
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- Eric Yuk Fai Wan
- Department of Family Medicine and Primary Care (E.Y.F.W., W.T.F., E.Y.T.Y., Y.W., C.L.K.L.)
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- Wing Tung Fung
- Department of Family Medicine and Primary Care (E.Y.F.W., W.T.F., E.Y.T.Y., Y.W., C.L.K.L.)
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- C. Mary Schooling
- School of Public Health, Li Ka Shing Faculty of Medicine (C.M.S., S.L.A.Y., M.K.K.)
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- Shiu Lun Au Yeung
- School of Public Health, Li Ka Shing Faculty of Medicine (C.M.S., S.L.A.Y., M.K.K.)
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- Esther Yee Tak Yu
- Department of Family Medicine and Primary Care (E.Y.F.W., W.T.F., E.Y.T.Y., Y.W., C.L.K.L.)
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- Yuan Wang
- Department of Family Medicine and Primary Care (E.Y.F.W., W.T.F., E.Y.T.Y., Y.W., C.L.K.L.)
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- Esther Wai Yin Chan
- Department of Pharmacology and Pharmacy, Centre for Safe Medication Practice and Research (E.W.Y.C.)
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- Ian Chi Kei Wong
- Department of Pharmacology and Pharmacy (E.Y.F.W., I.C.K.W.)
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- Cindy Lo Kuen Lam
- Department of Family Medicine and Primary Care (E.Y.F.W., W.T.F., E.Y.T.Y., Y.W., C.L.K.L.)
Bibliographic Information
- Other Title
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- A Mendelian Randomization Study
Description
<jats:p>This study aims to evaluate the causal association of blood pressure (BP) with cardiovascular diseases (CVDs). Two-sample Mendelian randomization was performed using a large genome-wide association study (n=299 024) and the UK Biobank cohort (n=375 256). We identified 327 and 364 single-nucleotide polymorphisms strongly and independently associated with systolic BP and diastolic BP, respectively, as genetic instruments to assess the causal association of BP with total CVD, CVD mortality, and 14 cardiovascular conditions. Nonlinearity was examined with nonlinear instrumental variable assumptions. Genetically predicted BP was significantly positively associated with total CVD (systolic BP, per 10 mm Hg: odds ratio [OR], 1.32 [95% CI, 1.25–1.40]; diastolic BP, per 5 mm Hg: OR, 1.20 [95% CI, 1.15–1.26]). Similar positive causal associations were observed for 14 cardiovascular conditions including ischemic heart disease (systolic BP, per 10 mm Hg: OR, 1.33 [95% CI, 1.24–1.41]; diastolic BP, per 5 mm Hg: OR, 1.20 [95% CI, 1.14–1.27]) and stroke (systolic BP, per 10 mm Hg: OR, 1.35 [95% CI, 1.24–1.48]; diastolic BP, per 5 mm Hg: OR, 1.20 [95% CI, 1.12–1.28]). Nonlinearity Mendelian randomization test demonstrated linear causal association of BP with these outcomes. Consistent estimates were observed in sensitivity analyses, suggesting robustness of the associations and minimal horizontal pleiotropy. The linear positive causal association of BP and CVD was consistent with previous findings that lower BP is better, thus consolidating clinical knowledge on hypertension management in CVD risk reduction.</jats:p>
Journal
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- Hypertension
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Hypertension 77 (2), 367-375, 2021-02
Ovid Technologies (Wolters Kluwer Health)
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Details 詳細情報について
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- CRID
- 1360579820064729856
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- ISSN
- 15244563
- 0194911X
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- Data Source
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- Crossref