Severe Acute Respiratory Syndrome Coronavirus 2–Induced Immune Activation and Death of Monocyte-Derived Human Macrophages and Dendritic Cells

DOI PDF PDF 被引用文献2件
  • Jian Zheng
    Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA
  • Yuhang Wang
    Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA
  • Kun Li
    Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA
  • David K Meyerholz
    Department of Pathology, University of Iowa, Iowa City, Iowa, USA
  • Chantal Allamargot
    Central Microscopy Research Facility, University of Iowa, Iowa City, Iowa, USA
  • Stanley Perlman
    Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA

抄録

<jats:title>Abstract</jats:title> <jats:p>Studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–infected patients and experimentally infected animals indicate a critical role for augmented expression of proinflammatory chemokines and cytokines in severe disease. Here, we demonstrate that SARS-CoV-2 infection of human monocyte-derived macrophages (MDMs) and monocyte-derived dendritic cells was abortive, but induced the production of multiple antiviral and proinflammatory cytokines (interferon-α, interferon-β, tumor necrosis factor, and interleukins 1β, 6, and 10) and a chemokine (CXCL10). Despite the lack of efficient replication in MDMs, SARS-CoV-2 induced profound interferon-mediated cell death of host cells. Macrophage activation and death were not enhanced by exposure to low levels of convalescent plasma, suggesting that antibody-dependent enhancement of infection does not contribute to cell death. Together, these results indicate that infection of macrophages and dendritic cells potentially plays a major role in coronavirus disease 2019 pathogenesis, even in the absence of productive infection.</jats:p>

収録刊行物

被引用文献 (2)*注記

もっと見る

問題の指摘

ページトップへ