Nearly free surface silanols are the critical molecular moieties that initiate the toxicity of silica particles
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- Cristina Pavan
- Louvain Centre for Toxicology and Applied Pharmacology, UCLouvain, 1200 Brussels, Belgium;
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- Rosangela Santalucia
- Department of Chemistry, University of Turin, 10124 Turin, Italy;
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- Riccardo Leinardi
- Louvain Centre for Toxicology and Applied Pharmacology, UCLouvain, 1200 Brussels, Belgium;
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- Marco Fabbiani
- Department of Chemistry, University of Turin, 10124 Turin, Italy;
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- Yousof Yakoub
- Louvain Centre for Toxicology and Applied Pharmacology, UCLouvain, 1200 Brussels, Belgium;
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- Francine Uwambayinema
- Louvain Centre for Toxicology and Applied Pharmacology, UCLouvain, 1200 Brussels, Belgium;
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- Piero Ugliengo
- Department of Chemistry, University of Turin, 10124 Turin, Italy;
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- Maura Tomatis
- Department of Chemistry, University of Turin, 10124 Turin, Italy;
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- Gianmario Martra
- Department of Chemistry, University of Turin, 10124 Turin, Italy;
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- Francesco Turci
- Department of Chemistry, University of Turin, 10124 Turin, Italy;
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- Dominique Lison
- Louvain Centre for Toxicology and Applied Pharmacology, UCLouvain, 1200 Brussels, Belgium;
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- Bice Fubini
- Department of Chemistry, University of Turin, 10124 Turin, Italy;
説明
<jats:title>Significance</jats:title> <jats:p>Silica particles with a population of nearly free silanols damage cellular membranes and initiate inflammatory reactions. Nearly free silanols are found on the surface of both fractured quartz and amorphous silica particles, and their occurrence initiates the toxicity of silica, thus revisiting the ancient paradigm whereby crystallinity is critical for silica toxicity. This finding resolves the lingering questions about the origin and the variability of the toxicity of silica particles. The discovery of the biological activity of nearly free silanols opens perspectives for the prevention of silicosis through a safer-by-design approach, and will have an impact on other fields that involve interfacial phenomena, including biomaterial design, nanofabrication, and catalysis.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 117 (45), 27836-27846, 2020-10-23
Proceedings of the National Academy of Sciences
