Enhancing the anti-inflammatory activity of chalcones by tuning the Michael acceptor site
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- Hannelore Rücker
- Institute of Organic Chemistry
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- Nafisah Al-Rifai
- Institute of Organic Chemistry
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- Anne Rascle
- Institute of Immunology
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- Eva Gottfried
- Department of Internal Medicine III
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- Lidia Brodziak-Jarosz
- Division of Redox Regulation
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- Clarissa Gerhäuser
- Division of Epigenomics and Cancer Risk Factors
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- Tobias P. Dick
- Division of Redox Regulation
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- Sabine Amslinger
- Institute of Organic Chemistry
書誌事項
- 公開日
- 2015
- DOI
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- 10.1039/c4ob02301c
- 公開者
- Royal Society of Chemistry (RSC)
この論文をさがす
説明
<p>Boosting the alkylation power of chalcones creates new anti-inflammatory agents. Thus NF-κB-dependent proteins are inhibited and Nrf2-dependent ones activated. The activity enhancement relies solely and very effectively on the α-substituent of the α,β-unsaturated carbonyl unit.</p>
収録刊行物
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- Organic & Biomolecular Chemistry
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Organic & Biomolecular Chemistry 13 (10), 3040-3047, 2015
Royal Society of Chemistry (RSC)