Lymphokines secreted by an established lymphocyte line modulate receptor-mediated endocytosis in macrophages derived from human monocytes.

DOI PDF 被引用文献1件
  • A M Fogelman
    Division of Cardiology, University of California at Los Angeles, School of Medicine , Los Angeles, CA 90024
  • J Seager
    Division of Cardiology, University of California at Los Angeles, School of Medicine , Los Angeles, CA 90024
  • J E Groopman
    Division of Hematology-Oncology, University of California at Los Angeles, School of Medicine , Los Angeles, CA 90024
  • J A Berliner
    Department of Pathology, University of California at Los Angeles, School of Medicine , Los Angeles, CA 90024
  • M E Haberland
    Division of Cardiology, University of California at Los Angeles, School of Medicine , Los Angeles, CA 90024
  • P A Edwards
    Department of Biological Chemistry, University of California at Los Angeles, School of Medicine , Los Angeles, CA 90024
  • D W Golde
    Department of Medicine, University of California at Los Angeles, School of Medicine , Los Angeles, CA 90024

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公開日
1983-11-01
権利情報
  • https://academic.oup.com/pages/standard-publication-reuse-rights
DOI
  • 10.4049/jimmunol.131.5.2368
公開者
Oxford University Press (OUP)

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<jats:title>Abstract</jats:title> <jats:p>As little as 1 microliter of serum-free supernatant from Mo(t), an established lymphocyte line, when added to a 500-microliters incubation of macrophages derived from human monocytes, significantly decreased the receptor-mediated uptake and degradation of three cholesterol-rich molecules: low density lipoprotein (LDL); LDL complexed to dextran sulfate; and LDL modified by malondialdehyde (MDA-LDL). In contrast, the receptor-mediated uptake and degradation of mannosyl bovine serum albumin was increased three-fold. The Mo(t) supernatant did not contain competitive inhibitors of the cholesterol-rich ligands, and it did not alter macrophage receptor-independent endocytosis, protein synthesis, or phagocytosis of heat-killed yeast. The effect of the Mo(t) supernatant was specific for macrophages and was abolished by preincubation of the supernatant with trypsin, which indicates that the active substances are protein in nature. The decrease in the uptake and degradation of MDA-LDL induced by preincubating the macrophages with Mo(t) supernatant appeared to result from a decrease in the number of receptors for this ligand at the cell surface. The isolation of these lymphokines should offer new insights into macrophage receptor-mediated endocytosis, and may yield substances useful in preventing foam cell formation in atherosclerosis.</jats:p>

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