Chronic pulmonary aspergillosis in a patient with hyper‐<scp>IgE</scp> syndrome

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  • Keisuke Kasuga
    Department of Respiratory Medicine Kyorin University School of Medicine Mitaka Japan
  • Keitaro Nakamoto
    Department of Respiratory Medicine Kyorin University School of Medicine Mitaka Japan
  • Kazuyuki Doi
    Department of Respiratory Medicine Kyorin University School of Medicine Mitaka Japan
  • Nozomi Kurokawa
    Department of Respiratory Medicine Kyorin University School of Medicine Mitaka Japan
  • Takeshi Saraya
    Department of Respiratory Medicine Kyorin University School of Medicine Mitaka Japan
  • Haruyuki Ishii
    Department of Respiratory Medicine Kyorin University School of Medicine Mitaka Japan

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<jats:title>Abstract</jats:title><jats:p>Hyperimmunoglobulin E (IgE) syndrome (HIES) is a rare disease with an unclear prognosis. We report a case of HIES comorbid with chronic pulmonary aspergillosis (CPA). A 19‐year‐old male was referred to our department with a medical history of bacterial pneumonia and skin infection. Laboratory data showed an elevated eosinophil count and serum IgE level. Chest computed tomography (CT) showed a pneumatocele and bronchiectasis. On the basis of the clinical and laboratory findings and genetic mutation analysis, we diagnosed him as having HIES. Fourteen months later, he complained of blood‐tinged sputum and haemoptysis. Chest CT showed pneumatocele wall thickening, fungus ball and consolidation. Serum <jats:italic>Aspergillus</jats:italic> precipitating antibody and serum galactomannan <jats:italic>Aspergillus</jats:italic> antigen were positive, and <jats:italic>Aspergillus fumigatus</jats:italic> was detected in the sputum. We diagnosed CPA and treated him using antifungal agents and bronchial artery embolization. CPA is a complication that requires attention in patients with HIES.</jats:p>

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