Comparative features and outcomes of major neurological complications of <scp>COVID</scp>‐19
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- Ettore Beghi
- Istituto di Ricerche Farmacologiche Mario Negri IRCCS Milan Italy
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- Elena Moro
- Centre Hospitalier Universitaire de Grenoble, Service de Neurologie, Grenoble Institute of Neurosciences Grenoble Alpes University Grenoble France
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- Eugenia Irene Davidescu
- Neurology Department, Colentina Clinical Hospital, Bucharest, Romania and Department of Clinical Neurosciences “Carol Davila” University of Medicine and Pharmacy Bucharest Romania
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- Bogdan Ovidiu Popescu
- Neurology Department, Colentina Clinical Hospital, Bucharest, Romania and Department of Clinical Neurosciences “Carol Davila” University of Medicine and Pharmacy Bucharest Romania
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- Oxana Grosu
- Diomid Gherman Institute of Neurology and Neurosurgery Chișinău Moldova
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- Franco Valzania
- Neurology Unit, Neuromotor and Rehabilitation Department Azienda USL‐IRCCS di Reggio Emilia Reggio Emilia Italy
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- Maria Sofia Cotelli
- Neurology Unit ASST Valcamonica Brescia Italy
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- Gordana Kiteva‐Trenchevska
- University Clinic for Neurology, Medical Faculty University "Ss. Cyril and Methodius" Skopje Macedonia
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- Maria Zakharova
- Department of the Research Centre of Neurology Moscow Russia
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- Tibor Kovács
- Semmelweis University Budapest Budapest Hungary
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- Carmel Armon
- Tel Aviv University School of Medicine and Shamir (Assaf Harofeh) Medical Center Tel Aviv Israel
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- Waldemar Brola
- Department of Neurology, Specialist Hospital Konskie, Collegium Medicum Jan Kochanowski University Kielce Poland
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- Clarissa Lin Yasuda
- CEPID BRAINN ‐ Brazilian Institute of Neuroscience and Neurotechnology and University of Campinas Campinas Brazil
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- Luís F. Maia
- Neurology Department Hospital Santo António – CHUP Porto Portugal
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- Arijana Lovrencic‐Huzjan
- Department of Neurology UHC Sestre milosrdnice Zagreb Croatia
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- Mafalda Maria Laracho de Seabra
- Department of Neurology Centro Hospitalar Universitário de São João, E.P.E Porto Spain
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- Rafael Avalos‐Pavon
- Neurology Service, Facultad de Medicina Universidad Autonoma de San Luis Potosi. Hospital Central San Luis Potosi Mexico
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- Anne Hege Aamodt
- Department of Neurology Oslo University Hospital Oslo Norway
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- Sara Meoni
- Centre Hospitalier Universitaire de Grenoble, Service de Neurologie, Grenoble Institute of Neurosciences Grenoble Alpes University Grenoble France
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- Victoria Gryb
- Department of Neurology and Neurosurgery Ivano‐Frankivsk National Medical University Ivano‐Frankivsk Ukraine
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- Serefnur Ozturk
- Selcuk University Faculty of Medicine Department of Neurology Konya Turkey
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- Omer Karadas
- University of Health Science Gulhane School of Medicine, Neurology Department Ankara Turkey
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- Ingomar Krehan
- Department of Neurology Kepler University Hospital Linz Austria
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- Maurizio A. Leone
- Istituto di Ricerche Farmacologiche Mario Negri IRCCS Milan Italy
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- Maria Lolich
- European Acadmey of Neurology Vienna Austria
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- Elisa Bianchi
- Istituto di Ricerche Farmacologiche Mario Negri IRCCS Milan Italy
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- Verena Rass
- Neurocritical Care Unit, Department of Neurology Medical University of Innsbruck Innsbruck Austria
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- Raimund Helbok
- Neurocritical Care Unit, Department of Neurology Medical University of Innsbruck Innsbruck Austria
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- Claudio L. A. Bassetti
- Department of Neurology University Hospital of Bern Bern Switzerland
抄録
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background and purpose</jats:title><jats:p>The aim of this study was to assess the neurological complications of SARS‐CoV‐2 infection and compare phenotypes and outcomes in infected patients with and without selected neurological manifestations.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>The data source was a registry established by the European Academy of Neurology during the first wave of the COVID‐19 pandemic. Neurologists collected data on patients with COVID‐19 seen as in‐ and outpatients and in emergency rooms in 23 European and seven non‐European countries. Prospective and retrospective data included patient demographics, lifestyle habits, comorbidities, main COVID‐19 complications, hospital and intensive care unit admissions, diagnostic tests, and outcome. Acute/subacute selected neurological manifestations in patients with COVID‐19 were analysed, comparing individuals with and without each condition for several risk factors.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>By July 31, 2021, 1523 patients (758 men, 756 women, and nine intersex/unknown, aged 16–101 years) were registered. Neurological manifestations were diagnosed in 1213 infected patients (79.6%). At study entry, 978 patients (64.2%) had one or more chronic general or neurological comorbidities. Predominant acute/subacute neurological manifestations were cognitive dysfunction (<jats:italic>N</jats:italic> = 449, 29.5%), stroke (<jats:italic>N</jats:italic> = 392, 25.7%), sleep–wake disturbances (<jats:italic>N</jats:italic> = 250, 16.4%), dysautonomia (<jats:italic>N</jats:italic> = 224, 14.7%), peripheral neuropathy (<jats:italic>N</jats:italic> = 145, 9.5%), movement disorders (<jats:italic>N</jats:italic> = 142, 9.3%), ataxia (<jats:italic>N</jats:italic> = 134, 8.8%), and seizures (<jats:italic>N</jats:italic> = 126, 8.3%). These manifestations tended to differ with regard to age, general and neurological comorbidities, infection severity and non‐neurological manifestations, extent of association with other acute/subacute neurological manifestations, and outcome.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Patients with COVID‐19 and neurological manifestations present with distinct phenotypes. Differences in age, general and neurological comorbidities, and infection severity characterize the various neurological manifestations of COVID‐19.</jats:p></jats:sec>
収録刊行物
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- European Journal of Neurology
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European Journal of Neurology 30 (2), 413-433, 2022-12-07
Wiley