Anticancer, Antibacterial, Antioxidant, and DNA-Binding Study of Metal-Phenalenyl Complexes
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- Subhadeep Sen
- Department of Chemistry, Cooch Behar Panchanan Barma University, Panchanan Nagar, Vivekananda Street, Cooch Behar 736101, West Bengal, India
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- Nilkanta Chowdhury
- Department of Biochemistry and Biophysics, University of Kalyani, Nadia 741235, West Bengal, India
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- Tae-Wan Kim
- Department of Medical Life Science, Soonchunhyang University, Asan 31538, Republic of Korea
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- Mohuya Paul
- Department of Electronic Materials, Devices, and Equipment Engineering, Soonchunhyang University, Asan 31538, Republic of Korea
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- Dilip Debnath
- Department of Chemistry, Cooch Behar Panchanan Barma University, Panchanan Nagar, Vivekananda Street, Cooch Behar 736101, West Bengal, India
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- Seob Jeon
- Department of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Republic of Korea
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- Angshuman Bagchi
- Department of Biochemistry and Biophysics, University of Kalyani, Nadia 741235, West Bengal, India
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- Jungkyun Im
- Department of Electronic Materials, Devices, and Equipment Engineering, Soonchunhyang University, Asan 31538, Republic of Korea
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- Goutam Biswas
- Department of Chemistry, Cooch Behar Panchanan Barma University, Panchanan Nagar, Vivekananda Street, Cooch Behar 736101, West Bengal, India
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- Massimiliano F. Peana
- editor
Abstract
<jats:p>Phenalenyl (PLY)-based metal complexes are a new addition to the metal complex family. Various applications of metal-based phenalenyl complexes (metal-PLY) have been reported, such as catalyst, quantum spin simulators, spin electronic devices, and molecular conductors, but the biological significance of metal-PLY (metal = Co(II), Mn(III), Ni(II), Fe(III), and Al(III)) systems has yet to be explored. In this study, the anticancer properties of such complexes were investigated in ovarian cancer cells (SKOV3 and HEY A8), and the cytotoxicity was comparable to that of other platinum-based drugs. Antibacterial activity of the metal-PLY complexes against both gram-negative (E. coli) and gram-positive (S. aureus) bacteria was studied using a disk diffusion test and minimum inhibitory concentration (MIC) methods. All five metal-PLY complexes showed significant antibacterial activity against both bacterial strains. The antioxidant properties of metal-PLY complexes were evaluated following the 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging method and were acceptable. The DNA-binding properties of these metal-PLY complexes were investigated using absorption spectroscopy, fluorescence spectroscopy, viscosity measurements, and thermal denaturation methods. Experimental evidence revealed that the complexes bind to DNA through intercalation, and the molecular docking study supported this conclusion.</jats:p>
Journal
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- Bioinorganic Chemistry and Applications
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Bioinorganic Chemistry and Applications 2022 1-15, 2022-04-14
Hindawi Limited
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Details 詳細情報について
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- CRID
- 1360579820498172544
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- ISSN
- 1687479X
- 15653633
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- Data Source
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- Crossref