Circular RNAs: A novel biomarker for cervical cancer

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  • Shala Chaichian
    Minimally Invasive Techniques Research Center in Women, Tehran Medical Sciences Branch Islamic Azad University Tehran Iran
  • Rana Shafabakhsh
    Research Center for Biochemistry and Nutrition in Metabolic Diseases Kashan University of Medical Sciences Kashan Iran
  • Seyyed Mehdi Mirhashemi
    Metabolic Diseases Research Center Qazvin University of Medical Sciences Qazvin Iran
  • Bahram Moazzami
    Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital Iran University of Medical Sciences Tehran Iran
  • Zatollah Asemi
    Research Center for Biochemistry and Nutrition in Metabolic Diseases Kashan University of Medical Sciences Kashan Iran

説明

<jats:title>Abstract</jats:title><jats:p>Besides messenger RNAs, recent RNA‐Seq and biochemical analysis showed another type of RNAs as a product of splicing which is named circular RNA (circRNA). Evidence demonstrated that circRNAs are abundant in the cells and are able to show cell/tissue‐specific expression or tissue developmental stage which suggest that circRNAs may have regulatory potentials. In recent years, researchers have focused attention on circRNAs because of their key functions in various cellular mechanisms. CircRNAs also have the potential to be as promising biomarkers for diagnosis of various diseases such as cancer. Growing up evidence has shown the various roles of circRNAs in multiple cancers. In recent years, cervical cancer as one of the main causes of cancer death in women has been interesting for molecular research. CircRNAs are one of the novel objects which have recently been evaluated in this cancer. The improvement in our knowledge of the roles of circRNAs in cervical cancer may lead to new transcription therapeutic approaches to cervical cancer inhibition. Therefore, the purpose of this review is to review many studies which examined the role of circRNAs in cervical cancer carcinogenesis and progression up till date and to summarize possible mechanisms of action of circRNAs in cervical neoplasm.</jats:p>

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